Recent Advances in Biocompatible Ionic Liquids in Drug Formulation and Delivery.
Recent Advances in Biocompatible Ionic Liquids in Drug Formulation and Delivery.
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DOI：
10.3390/pharmaceutics15041179
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发表时间：
2023-04-07
期刊：
影响因子：
5.4
通讯作者：
Goto M
中科院分区：
文献类型：
--
作者：
Moshikur RM;Carrier RL;Moniruzzaman M;Goto M
为新开发或上市的药物分子开发有效的药物制剂和递送系统仍然是一个重大挑战。这些药物可能表现出多晶型转化、差的生物利用度和全身毒性，并且由于急性毒性而难以用传统有机溶剂配制。离子液体是一种能够改善药物药代动力学和药效学的溶剂。离子液体可以解决与传统有机溶剂相关的操作/功能挑战。然而，许多IL是不可生物降解的并且固有地有毒，这是开发基于IL的药物制剂和递送系统的最重大挑战。包含主要来源于生物可再生来源的生物相容性阳离子和阴离子的生物相容性IL被认为是常规IL和有机/无机溶剂的绿色替代物。本文综述了为设计生物相容性离子液体而开发的技术和策略，重点关注生物相容性离子液体药物制剂和递送系统的设计，并讨论了这些离子液体在制药和生物医学应用中的优势。此外，这篇综述将为从化学合成到制药领域向生物相容性离子液体过渡而不是向常用的有毒离子液体和有机溶剂过渡提供指导。
The development of effective drug formulations and delivery systems for newly developed or marketed drug molecules remains a significant challenge. These drugs can exhibit polymorphic conversion, poor bioavailability, and systemic toxicity, and can be difficult to formulate with traditional organic solvents due to acute toxicity. Ionic liquids (ILs) are recognized as solvents that can improve the pharmacokinetic and pharmacodynamic properties of drugs. ILs can address the operational/functional challenges associated with traditional organic solvents. However, many ILs are non-biodegradable and inherently toxic, which is the most significant challenge in developing IL-based drug formulations and delivery systems. Biocompatible ILs comprising biocompatible cations and anions mainly derived from bio-renewable sources are considered a green alternative to both conventional ILs and organic/inorganic solvents. This review covers the technologies and strategies developed to design biocompatible ILs, focusing on the design of biocompatible IL-based drug formulations and delivery systems, and discusses the advantages of these ILs in pharmaceutical and biomedical applications. Furthermore, this review will provide guidance on transitioning to biocompatible ILs rather than commonly used toxic ILs and organic solvents in fields ranging from chemical synthesis to pharmaceutics.
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影响因子：
19
作者：
Angsantikul, Pavimol;Peng, Kevin;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
3.8
作者：
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通讯作者：
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影响因子：
6
作者：
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通讯作者：
Cakan-Akdogan, Gulcin
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影响因子：
3.9
作者：
通讯作者：
--
影响因子：
5.4
作者：
Alves MMS;Melo MN;Mertens HDT;Pereiro AB;Archer M
通讯作者：
Archer M