High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
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RAD51的高级表达是非小细胞肺癌患者生存的独立预后标志。
DOI：
10.1038/sj.bjc.6602665
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发表时间：
2005-07-11
影响因子：
8.8
通讯作者：
Stuerzbecher, HW
中科院分区：
文献类型：
--
作者：
Qiao, GB;Wu, YL;Yang, XN;Zhong, WZ;Xie, D;Guan, XY;Fischer, D;Kolberg, HC;Kruger, S;Stuerzbecher, HW
Rad 51是同源重组中的关键因子，在多种人类恶性肿瘤中观察到其高水平表达。本研究旨在评估Rad 51表达作为非小细胞肺癌（NSCLC）预后标志物的价值。共383个非小细胞肺肿瘤进行了非小细胞肺癌组织微阵列化学分析。在29.4%（100/340）的病例中观察到高水平的Rad 51表达。肿瘤显示高水平Rad 51表达的患者的中位生存时间显着缩短，为19个月对68个月（P<0.0001，对数秩检验）。同样，T状态、N状态、M状态、临床分期和组织学肿瘤分级在单变量考克斯生存分析中是显著的预后标志。重要的是，Rad 51表达（P<0.0001）与肿瘤分化（P<0.009），临床分期（P=0.004）和N状态（P=0.0001）在多变量分析中被证明是独立的预后参数。Rad 51表达预测肺鳞状细胞癌和肺腺癌的结果。我们的研究结果表明，Rad 51的表达提供了额外的预后信息手术治疗的NSCLC患者。我们假设Rad 51高水平表达的NSCLC患者的生存率降低与肿瘤细胞的生存、抗凋亡和化疗/放射抗性的倾向增强有关。
High-level expression of Rad51, a key factor in homologous recombination, has been observed in a variety of human malignancies. This study was aimed to evaluate Rad51 expression to serve as prognostic marker in non-small-cell lung cancer (NSCLC). A total of 383 non-small-cell lung tumours were analysed immunohistochemically on NSCLC tissue microarrays. High-level Rad51 expression was observed in 29.4% (100 out of 340) of cases. Patients whose tumours displayed high-level Rad51 expression showed a significantly shorter median survival time of 19 vs 68 months (P<0.0001, log-rank test). Similarly T status, N status, M status, clinical stage and histological tumour grade were significant prognostic markers in univariate Cox survival analysis. Importantly, Rad51 expression (P<0.0001) together with tumour differentiation (P<0.009), clinical stage (P=0.004) and N status (P=0.0001) proved to be independent prognostic parameters in multivariate analysis. Rad51 expression predicted the outcome of squamous cell cancer as well as adenocarcinoma of the lung. Our results suggest that Rad51 expression provides additional prognostic information for surgically treated NSCLC patients. We hypothesise that the decreased survival of NSCLC patients with high-level expression of Rad51 is related to an enhanced propensity of tumour cells for survival, antiapoptosis and chemo-/radioresistance.
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侵入性导管乳腺癌的形态分级。 I.核等级的阈值。
影响因子：
8.8
作者：
Kronqvist, P;Kuopio, T;Collan, Y
通讯作者：
Collan, Y
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作者：
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影响因子：
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作者：
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