RING-Domain E3 Ligase-Mediated Host-Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses.
RING-Domain E3 Ligase-Mediated Host-Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses.
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RING域E3连接酶介导的宿主-病毒相互作用：协调宿主的免疫反应并对抗病毒的免疫防御
DOI：
10.3389/fimmu.2018.01083
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发表时间：
2018
影响因子：
7.3
通讯作者：
Qiu HJ
中科院分区：
文献类型：
--
作者：
Zhang Y;Li LF;Munir M;Qiu HJ
RING结构域E3连接酶（RING E3 s）是一组含有一个或两个RING指结构域的E3连接酶，其参与多种细胞过程，例如细胞增殖、免疫调节、凋亡等。在宿主中，大量的RING E3通过调节免疫应答来抑制病毒复制，包括激活和抑制视黄酸诱导的基因I样受体、toll样受体和DNA受体信号通路，调节主要组织相容性复合物的细胞表面表达，以及共刺激分子。在进化和适应过程中，病毒编码RING E3来拮抗宿主的免疫防御，例如单纯疱疹病毒1型的感染细胞蛋白0、轮状病毒的非结构蛋白1以及卡波西肉瘤相关疱疹病毒的K3和K5。此外，最近的研究表明，病毒可以劫持宿主RING E3以促进病毒复制。基于新的有趣发现，RING E3在宿主和病毒之间呈现了新的联系。本文就RING E3 s介导的宿主-病毒相互作用的最新研究进展进行综述，并对RING E3 s的研究前景进行展望。
The RING-domain E3 ligases (RING E3s), a group of E3 ligases containing one or two RING finger domains, are involved in various cellular processes such as cell proliferation, immune regulation, apoptosis, among others. In the host, a substantial number of the RING E3s have been implicated to inhibit viral replication through regulating immune responses, including activation and inhibition of retinoic acid-inducible gene I-like receptors, toll-like receptors, and DNA receptor signaling pathways, modulation of cell-surface expression of major histocompatibility complex, and co-stimulatory molecules. During the course of evolution and adaptation, viruses encode RING E3s to antagonize host immune defense, such as the infected cell protein 0 of herpes simplex virus type 1, the non-structural protein 1 of rotavirus, and the K3 and K5 of Kaposi’s sarcoma-associated herpesvirus. In addition, recent studies suggest that viruses can hijack the host RING E3s to facilitate viral replication. Based on emerging and interesting discoveries, the RING E3s present novel links among the host and viruses. Herein, we focus on the latest research progresses in the RING E3s-mediated host–virus interactions and discuss the outlooks of the RING E3s for future research.
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影响因子：
7.6
作者：
BARON, S;DIANZANI, F
通讯作者：
DIANZANI, F
DOI：
10.4049/jimmunol.1101643
发表时间：
2011-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Baravalle G;Park H;McSweeney M;Ohmura-Hoshino M;Matsuki Y;Ishido S;Shin JS
通讯作者：
Shin JS
影响因子：
3.5
作者：
Capon, Francesca;Bijlmakers, Marie-Jose;Trembath, Richard C.
通讯作者：
Trembath, Richard C.
影响因子：
5.4
作者：
Bartee, E;Mansouri, M;Früh, K
通讯作者：
Früh, K
影响因子：
5.4
作者：
Bharaj, Preeti;Atkins, Colm;Rajsbaum, Ricardo
通讯作者：
Rajsbaum, Ricardo