Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging.
Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging.
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DOI：
10.1016/j.jalz.2014.09.001
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发表时间：
2014-11
影响因子：
14
通讯作者：
Petersen, Ronald C.
中科院分区：
文献类型：
--
作者：
Mielke, Michelle M.;Weigand, Stephen D.;Wiste, Heather J.;Vemuri, Prashanthi;Machulda, Mary M.;Knopman, Davis S.;Lowe, Val;Roberts, Rosebud O.;Kantarci, Kejal;Rocca, Walter A.;Jack, Clifford R., Jr.;Petersen, Ronald C.
关键词：
需要用于评估阿尔茨海默型病理生理学的廉价的非侵入性工具。计算机化的认知评估是主要的候选人。纳入了认知正常的参与者，年龄在51-71岁之间，进行了MRI，FDG-PET，淀粉样蛋白PET，CogState计算机认知评估和标准神经心理学测试。我们首先研究了CogState电池和神经影像学测量之间的关联。然后，我们将这种关联与标准神经心理学z分数和神经影像学之间的关联进行了比较。CogState Identification和One Back的反应时间较慢，记忆力和注意力Z分数较低，与FDG-PET代谢低下相关（P<0.05）。在格罗顿迷宫学习任务上的较慢的时间和较差的单卡学习准确性与较小的海马体积相关（P<0.05）。与淀粉样蛋白PET没有关联。CogState和神经心理学z分数与神经影像学的关联很小，并且幅度相似。CogState子测试与标准神经心理学测试相比，其与神经变性成像标记物的关联相对较弱。
Inexpensive, non-invasive tools for assessing Alzheimer-type pathophysiologies are needed. Computerized cognitive assessments are prime candidates. Cognitively normal participants, aged 51-71, with MRI, FDG-PET, amyloid PET, CogState computerized cognitive assessment, and standard neuropsychological tests were included. We first examined the association between the CogState battery and neuroimaging measures. We then compared that association to the one between standard neuropsychological z-scores and neuroimaging. Slower reaction times for CogState Identification and One Back, and lower memory and attention z-scores, were associated (P<.05) with FDG-PET hypometabolism. Slower time on the Groton Maze Learning Task and worse One Card Learning accuracy were associated (P<.05) with smaller hippocampal volumes. There were no associations with amyloid PET. Associations of CogState and neuropsychological z-scores with neuroimaging were small and of a similar magnitude. CogState subtests were cross-sectionally comparable to standard neuropsychological tests in their relatively weak associations with neurodegeneration imaging markers.
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