Role of bile acids in inflammatory liver diseases.
Role of bile acids in inflammatory liver diseases.
复制标题
DOI：
10.1007/s00281-021-00869-6
复制
发表时间：
2021-08
影响因子：
9
通讯作者：
Kuipers F
中科院分区：
文献类型：
--
作者：
Evangelakos I;Heeren J;Verkade E;Kuipers F
胆汁酸及其信号通路越来越被认为是胆汁淤积性和代谢性肝病的潜在治疗靶点。这篇综述总结了胆汁酸生理学的新见解，重点是胆汁酸在免疫调节控制中的调节作用，以及胆汁酸信号通路的药理学调节剂在人类肝脏疾病中的作用。最近的小鼠研究强调了胆汁酸和肠道微生物组之间相互作用的重要性。干扰微生物组组成可能通过调节次级胆汁酸的形成而有益于胆汁淤积性和代谢性肝病，因为不同的胆汁酸种类具有不同的信号传导功能。胆汁酸受体如FXR、VDR和TGR 5在参与先天性和适应性免疫的多种细胞中表达，并且特异性微生物胆汁酸代谢物积极调节宿主的免疫应答。Cyp 2c 70作为负责产生亲水性小鼠/大鼠特异性鼠胆酸的酶的鉴定允许产生具有人样胆汁酸组成的鼠模型。这些新的小鼠模型将有助于加速胆汁酸在人类肝脏疾病中的（病理）生理作用的转化研究。
Bile acids and their signaling pathways are increasingly recognized as potential therapeutic targets for cholestatic and metabolic liver diseases. This review summarizes new insights in bile acid physiology, focusing on regulatory roles of bile acids in the control of immune regulation and on effects of pharmacological modulators of bile acid signaling pathways in human liver disease. Recent mouse studies have highlighted the importance of the interactions between bile acids and gut microbiome. Interfering with microbiome composition may be beneficial for cholestatic and metabolic liver diseases by modulating formation of secondary bile acids, as different bile acid species have different signaling functions. Bile acid receptors such as FXR, VDR, and TGR5 are expressed in a variety of cells involved in innate as well as adaptive immunity, and specific microbial bile acid metabolites positively modulate immune responses of the host. Identification of Cyp2c70 as the enzyme responsible for the generation of hydrophilic mouse/rat-specific muricholic acids has allowed the generation of murine models with a human-like bile acid composition. These novel mouse models will aid to accelerate translational research on the (patho)physiological roles of bile acids in human liver diseases .
登录
查看更多内容
影响因子：
64.8
作者：
Chen ML;Huang X;Wang H;Hegner C;Liu Y;Shang J;Eliason A;Diao H;Park H;Frey B;Wang G;Mosure SA;Solt LA;Kojetin DJ;Rodriguez-Palacios A;Schady DA;Weaver CT;Pipkin ME;Moore DD;Sundrud MS
通讯作者：
Sundrud MS
DOI：
10.1097/meg.0b013e328345c8c7
发表时间：
2011-05
影响因子：
2.1
作者：
Dasarathy S;Yang Y;McCullough AJ;Marczewski S;Bennett C;Kalhan SC
通讯作者：
Kalhan SC
影响因子：
13.5
作者：
BEUERS, U;SPENGLER, U;PAUMGARTNER, G
通讯作者：
PAUMGARTNER, G
影响因子：
13.5
作者：
Bechmann, Lars P.;Kocabayoglu, Peri;Canbay, Ali
通讯作者：
Canbay, Ali
人类脂肪肝病：旧问题和新见解。
DOI：
10.1126/science.1204265
发表时间：
2011-06-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cohen JC;Horton JD;Hobbs HH
通讯作者：
Hobbs HH