Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.
Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.
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DOI：
10.1021/ja104501a
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发表时间：
2010-09-15
影响因子：
15
通讯作者：
Nel, Andre E.
中科院分区：
文献类型：
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作者：
Meng, Huan;Xue, Min;Xia, Tian;Zhao, Yan-Li;Tamanoi, Fuyuhiko;Stoddart, J. Fraser;Zink, Jeffrey I.;Nel, Andre E.
介孔二氧化硅纳米颗粒（MSNP）已被证明是用于受控药物递送的极其有效的固体载体，因为它们的表面可以容易地官能化以控制纳米孔开口。我们最近已经描述了一系列机械化的二氧化硅纳米颗粒，其在非生物条件下，能够采用一系列纳米阀递送货物分子。这些系统的关键问题现在已经变成了它们是否可以通过控制细胞中的纳米阀打开来适应生物用途。本文中，我们报告了一种新型的MSNP递送系统，其能够基于β-环糊精（β-CD）纳米阀的功能进行药物递送，所述β-环糊精纳米阀响应于人分化骨髓（THP-1）和鳞状细胞癌（KB-31）细胞系中的内体酸化条件。此外，我们展示了如何优化MSNP的表面功能化，从而为有效和快速地将阿霉素释放到KB-31细胞核中提供平台。
Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of β-cyclodextrin (β-CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB-31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells.
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DOI：
10.1073/pnas.75.7.3327
发表时间：
1978-01-01
影响因子：
11.1
作者：
OHKUMA, S;POOLE, B
通讯作者：
POOLE, B
影响因子：
19
作者：
Angelos, Sarah;Johansson, Erik;Zink, Jeffrey I.
通讯作者：
Zink, Jeffrey I.
影响因子：
4.7
作者：
Bae, Younsoo;Nishiyama, Nobuhiro;Kataoka, Kazunori
通讯作者：
Kataoka, Kazunori
影响因子：
15
作者：
Liu, Rui;Zhang, Ying;Feng, Pingyun
通讯作者：
Feng, Pingyun
影响因子：
41.2
作者：
通讯作者：
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