Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease.
Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease.
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DOI：
10.1093/brain/awn047
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发表时间：
2008-05
期刊：
影响因子：
--
通讯作者：
Boxer AL
中科院分区：
文献类型：
--
作者：
Garbutt S;Matlin A;Hellmuth J;Schenk AK;Johnson JK;Rosen H;Dean D;Kramer J;Neuhaus J;Miller BL;Lisberger SG;Boxer AL
额颞叶变性（FTLD）在临床上常与皮质基底综合征（CBS）和进行性核上性麻痹（PSP）重叠，两者均有明显的眼动异常。为了研究眼动功能区分FTLD、阿尔茨海默病、CBS和PSP的能力，我们测量了3种FTLD亚型的扫视和平滑追踪，其中包括24例额颞叶痴呆（FTD）、19例语义痴呆（SD）和6例进行性非流畅性失语症（PA），与之相比，阿尔茨海默病28例、CBS 15例、PSP 10例和27例对照受试者。除SD外，所有临床综合征均发现了不同的动眼肌异常组合，SD的动眼肌表现与年龄匹配的对照组没有区别。只有PSP患者表现出眼跳速度异常，而在PSP > CBS >阿尔茨海默病患者中观察到眼跳增加异常。除SD患者外，所有患者组在抗扫视任务上都受损，但只有FTLD受试者和阿尔茨海默病、CBS或PSP组能够自发地自我纠正抗扫视错误，与对照组一样。受者操作特征统计表明，在区分PSP与其他疾病方面，动眼肌检查优于神经心理测试，在区分其他患者组方面，与神经心理测试相当。这些数据表明，动眼力评估可能有助于诊断FTLD和相关疾病。
Frontotemporal lobar degeneration (FTLD) often overlaps clinically with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP), both of which have prominent eye movement abnormalities. To investigate the ability of oculomotor performance to differentiate between FTLD, Alzheimer's disease, CBS and PSP, saccades and smooth pursuit were measured in three FTLD subtypes, including 24 individuals with frontotemporal dementia (FTD), 19 with semantic dementia (SD) and six with progressive non-fluent aphasia (PA), as compared to 28 individuals with Alzheimer's disease, 15 with CBS, 10 with PSP and 27 control subjects. Different combinations of oculomotor abnormalities were identified in all clinical syndromes except for SD, which had oculomotor performance that was indistinguishable from age-matched controls. Only PSP patients displayed abnormalities in saccade velocity, whereas abnormalities in saccade gain were observed in PSP > CBS > Alzheimer's disease subjects. All patient groups except those with SD were impaired on the anti-saccade task, however only the FTLD subjects and not Alzheimer's disease, CBS or PSP groups, were able to spontaneously self-correct anti-saccade errors as well as controls. Receiver operating characteristic statistics demonstrated that oculomotor findings were superior to neuropsychological tests in differentiating PSP from other disorders, and comparable to neuropsychological tests in differentiating the other patient groups. These data suggest that oculomotor assessment may aid in the diagnosis of FTLD and related disorders.
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影响因子：
--
作者：
CURRIE, J;RAMSDEN, B;MARUFF, P
通讯作者：
MARUFF, P
影响因子：
2.4
作者：
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11.2
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通讯作者：
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14.5
作者：
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通讯作者：
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