To the end of the line: Axonal mRNA transport and local translation in health and neurodegenerative disease.
To the end of the line: Axonal mRNA transport and local translation in health and neurodegenerative disease.
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DOI：
10.1002/dneu.22555
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发表时间：
2018-03
影响因子：
3
通讯作者：
Willis DE
中科院分区：
文献类型：
--
作者：
Costa CJ;Willis DE
轴突和生长锥体本质上远离细胞体，会遇到独特的环境，需要不同的蛋白质群体。因此，他们已经开发出在本地合成执行其特殊功能所需的大量蛋白质的机制，这似乎是很自然的。接受这种能力已经花了几十年的时间；然而，现在的共识是，轴突确实具有进行局部翻译的能力，而且这种能力甚至会保留到成年。越来越多的证据支持局部合成的蛋白质在神经元的正常发育、维持和功能中的作用，新出现的研究也表明，这一过程的中断与许多神经发育和神经退行性疾病有关。在这里，我们简要回顾轴突mRNA定位和局部翻译的悠久历史，以及这些局部合成的蛋白质在正常神经元功能中所起的作用。此外，我们重点介绍了新的证据表明，这些过程中的失调导致了广泛的病理生理学，包括神经精神障碍、阿尔茨海默氏症和运动神经元疾病，如脊髓性肌萎缩和肌萎缩侧索硬化症。
Axons and growth cones, by their very nature far removed from the cell body, encounter unique environments and require distinct populations of proteins. It seems only natural, then, that they have developed mechanisms to locally synthesize a host of proteins required to perform their specialized functions. Acceptance of this ability has taken decades; however, there is now consensus that axons do indeed have the capacity for local translation, and that this capacity is even retained into adulthood. Accumulating evidence supports the role of locally synthesized proteins in the proper development, maintenance, and function of neurons, and newly emerging studies also suggest that disruption in this process has implications in a number of neurodevelopmental and neurodegenerative diseases. Here, we briefly review the long history of axonal mRNA localization and local translation, and the role that these locally synthesized proteins play in normal neuronal function. Additionally, we highlight the emerging evidence that dysregulation in these processes contributes to a wide range of pathophysiology, including neuropsychiatric disorders, Alzheimer’s, and motor neuron diseases such as Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis.
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影响因子：
5.8
作者：
Deglincerti A;Jaffrey SR
通讯作者：
Jaffrey SR
影响因子：
25
作者：
Cosker KE;Fenstermacher SJ;Pazyra-Murphy MF;Elliott HL;Segal RA
通讯作者：
Segal RA
影响因子：
16.2
作者：
Alami NH;Smith RB;Carrasco MA;Williams LA;Winborn CS;Han SSW;Kiskinis E;Winborn B;Freibaum BD;Kanagaraj A;Clare AJ;Badders NM;Bilican B;Chaum E;Chandran S;Shaw CE;Eggan KC;Maniatis T;Taylor JP
通讯作者：
Taylor JP
影响因子：
3.5
作者：
Akins, Michael R.;Berk-Rauch, Hanna E.;Fallon, Justin R.
通讯作者：
Fallon, Justin R.
DOI：
10.1073/pnas.0607394104
发表时间：
2006-12-26
影响因子：
11.1
作者：
Bi, Jing;Tsai, Nien-Pei;Wei, Li-Na
通讯作者：
Wei, Li-Na