Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury.
Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury.
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DOI：
10.3389/fnins.2021.755902
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发表时间：
2021
影响因子：
4.3
通讯作者：
Tang H
中科院分区：
文献类型：
--
作者：
Kang X;Su S;Hong W;Geng W;Tang H
脑卒中是一种起病突然、发病率和死亡率高的疾病，临床治疗困难。中医药在临床实践中的应用越来越广泛。现代药理学研究发现，黄芪具有多种药用特性，即，免疫调节、抗氧化、抗癌、抗糖尿病、心肌保护、保肝和抗病毒功能。本文综述了从黄芪中提取的黄芪甲苷对脑卒中的保护作用及其机制，探讨了黄芪甲苷对脑缺血再灌注相关并发症的保护作用，并展望了其研究前景，拓展了中西医结合治疗策略和药物的思路，为脑缺血的临床治疗提供理论参考-再灌注损伤和改善卒中预后。
Stroke, a disease with a sudden onset and high morbidity and mortality rates, is difficult to treat in the clinic. Traditional Chinese medicine has become increasingly widely used in clinical practice. Modern pharmacological studies have found that Radix Astragali has a variety of medicinal properties, i.e., immunoregulatory, antioxidative, anti-cancer, anti-diabetes, myocardial protective, hepatoprotective, and antiviral functions. This article reviews the protective effect and mechanism of astragaloside IV, which is extracted from Radix Astragali, on stroke, discusses the cerebroprotective effect of astragaloside IV against ischemia-reperfusion-related complications, offers insight into research prospects, and expands the idea of integrating traditional Chinese and Western medicine treatment strategies and drugs to provide a theoretical reference for the clinical treatment of cerebral ischemia-reperfusion injury and the improvement of stroke prognosis.
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影响因子：
2.9
作者：
Huang Xiao-ping;Tan Hua;Deng Chang-qing
通讯作者：
Deng Chang-qing
影响因子：
6.9
作者：
Kinouchi T;Kitazato KT;Shimada K;Yagi K;Tada Y;Matsushita N;Kurashiki Y;Satomi J;Sata M;Nagahiro S
通讯作者：
Nagahiro S
重复电针预处理减弱大鼠局灶性脑缺血后基质金属蛋白酶9的表达和活性
影响因子：
1.9
作者：
Dong, Hui;Fan, Yan-Hong;Xiong, Li-Ze
通讯作者：
Xiong, Li-Ze
影响因子：
5.5
作者：
Abdullahi, Wazir;Tripathi, Dinesh;Ronaldson, Patrick T.
通讯作者：
Ronaldson, Patrick T.
EGFR 介导黄芪甲苷 IV 诱导的 Nrf2 激活，以保护皮质神经元免受体外缺血/再灌注损伤。
DOI：
10.1016/j.bbrc.2015.01.002
发表时间：
2015-02-13
影响因子：
3.1
作者：
Gu, Da-min;Lu, Pei-Hua;Wang, Qiong
通讯作者：
Wang, Qiong