Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.
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DOI：
10.1016/j.neuron.2008.11.024
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发表时间：
2009-01-29
期刊：
影响因子：
16.2
通讯作者：
Frank, Marcos G.
中科院分区：
文献类型：
--
作者：
Halassa, Michael M.;Florian, Cedrick;Fellin, Tommaso;Munoz, James R.;Lee, So-Young;Abel, Ted;Haydon, Philip G.;Frank, Marcos G.
星形胶质细胞通过释放化学递质来调节神经元活动，这一过程被称为胶质传递。这一过程在行为控制中的作用尚不清楚。由于依赖于snare的胶质传递的一个结果是调节细胞外腺苷，并且由于腺苷促进睡眠，我们从基因上抑制胶质递质的释放，并询问星形胶质细胞是否在睡眠调节中发挥了未被怀疑的作用。通过测量非快速眼动睡眠期间脑电图的慢波活动来评估，抑制胶质传递减弱了睡眠压力的积累，并预防了与睡眠缺失相关的认知缺陷。由于A1受体拮抗剂CPT的睡眠抑制作用在胶质传递抑制后被阻止，并且由于CPT在野生型小鼠脑室内递送模仿转基因表型，我们得出结论，星形胶质细胞通过涉及A1受体的途径调节睡眠压力的积累及其认知后果。
Astrocytes modulate neuronal activity by releasing chemical transmitters via a process termed gliotransmission. The role of this process in the control of behavior is unknown. Since one outcome of SNARE-dependent gliotransmission is the regulation of extracellular adenosine and because adenosine promotes sleep, we genetically inhibited the release of gliotransmitters and asked if astrocytes play an unsuspected role in sleep regulation. Inhibiting gliotransmission attenuated the accumulation of sleep pressure, assessed by measuring the slow wave activity of the EEG during NREM sleep and prevented cognitive deficits associated with sleep loss. Since the sleep-suppressing effects of the A1 receptor antagonist CPT were prevented following inhibition of gliotransmission and because intracerebroventricular delivery of CPT to wildtype mice mimicked the transgenic phenotype we conclude that astrocytes modulate the accumulation of sleep pressure and its cognitive consequences through a pathway involving A1 receptors.
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影响因子：
56.9
作者：
Nakashiba, Toshiaki;Young, Jennie Z.;Tonegawa, Susumu
通讯作者：
Tonegawa, Susumu
影响因子：
30.8
作者：
Kapfhamer, D;Valladares, O;Bucan, M
通讯作者：
Bucan, M
影响因子：
56.9
作者：
Porkka-Heiskanen, T;Strecker, RE;McCarley, RW
通讯作者：
McCarley, RW
影响因子：
56.9
作者：
Pascual, O;Casper, KB;Haydon, PG
通讯作者：
Haydon, PG
DOI：
10.1073/pnas.0505414102
发表时间：
2005-10-25
影响因子：
11.1
作者：
Rétey, JV;Adam, M;Landolt, HP
通讯作者：
Landolt, HP