RefSeq microbial genomes database: new representation and annotation strategy.
RefSeq microbial genomes database: new representation and annotation strategy.
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DOI：
10.1093/nar/gkt1274
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发表时间：
2014-01
影响因子：
14.9
通讯作者：
Tolstoy I
中科院分区：
文献类型：
--
作者：
Tatusova T;Ciufo S;Fedorov B;O'Neill K;Tolstoy I
RefSeq集合中微生物基因组序列的来源是提交给国际核苷酸序列数据库公共档案的一级序列记录集。这些可以通过http://www.ncbi.nlm.nih.gov/genome上的Escherz搜索和检索系统访问。下一代测序使研究人员能够以过去无法想象的速度进行基因组测序。微生物基因组现在可以在几个小时内测序，这导致了公共档案馆中保存的组装基因组数量的显着增加。DNA序列数据的巨大增长对生物信息学工具的注释、分析和可视化提出了新的挑战。已经开发了用于注释和表示参考基因组和来自人群研究和临床爆发的序列变异的新策略。
The source of the microbial genomic sequences in the RefSeq collection is the set of primary sequence records submitted to the International Nucleotide Sequence Database public archives. These can be accessed through the Entrez search and retrieval system at http://www.ncbi.nlm.nih.gov/genome. Next-generation sequencing has enabled researchers to perform genomic sequencing at rates that were unimaginable in the past. Microbial genomes can now be sequenced in a matter of hours, which has led to a significant increase in the number of assembled genomes deposited in the public archives. This huge increase in DNA sequence data presents new challenges for the annotation, analysis and visualization bioinformatics tools. New strategies have been developed for the annotation and representation of reference genomes and sequence variations derived from population studies and clinical outbreaks.
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影响因子：
5.8
作者：
Zhou, Jindan;Richardson, Andrew J.;Rudd, Kenneth E.
通讯作者：
Rudd, Kenneth E.
影响因子：
14.9
作者：
Kodama Y;Shumway M;Leinonen R;International Nucleotide Sequence Database Collaboration
通讯作者：
International Nucleotide Sequence Database Collaboration
影响因子：
56.9
作者：
FLEISCHMANN, RD;ADAMS, MD;VENTER, JC
通讯作者：
VENTER, JC
影响因子：
14.9
作者：
Nakamura Y;Cochrane G;Karsch-Mizrachi I;International Nucleotide Sequence Database Collaboration
通讯作者：
International Nucleotide Sequence Database Collaboration
影响因子：
5.8
作者：
Tatusova, TA;Karsch-Mizrachi, I;Ostell, JA
通讯作者：
Ostell, JA