Plant Alkaloids as Antiplatelet Agent: Drugs of the Future in the Light of Recent Developments.
Plant Alkaloids as Antiplatelet Agent: Drugs of the Future in the Light of Recent Developments.
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DOI：
10.3389/fphar.2016.00292
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发表时间：
2016
影响因子：
5.6
通讯作者：
Pervaiz A
中科院分区：
文献类型：
--
作者：
Ain QU;Khan H;Mubarak MS;Pervaiz A
生物碱是一类天然存在的有机含氮化合物，经常在植物界发现。许多生物碱是有价值的医药剂，可用于治疗各种疾病，包括疟疾，糖尿病，癌症，心脏功能障碍等。同样，血小板聚集超出稳态的目的是凝血相关疾病的根本原因。本文根据近十年来的文献，对生物碱类抗血小板药物及其可能的作用机制进行了综述。此外，本文将讨论生物碱的抗血小板活性及其作为强效抗血小板药物的药用用途，并描述其结构关系、活性和可能的先导化合物，以供未来药物发现之用。
An alkaloid is a class of naturally occurring organic nitrogen-containing compounds that are frequently found in the plant kingdom. Many alkaloids are valuable medicinal agents that can be utilized to treat various diseases including malaria, diabetics, cancer, cardiac dysfunction etc. Similarly, platelet aggregation beyond the purpose of homeostasis is the underlying cause of blood clotting related diseases. This review presents a thorough understanding of alkaloids as antiplatelet agents with a possible mechanism of action based on the literature of the last decade. In addition, this review will address the antiplatelet activity of alkaloids and their medicinal usage as potent antiplatelet agents with a description of structural relationship activity and possible lead compounds for future drug discovery.
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