Hemodynamic and respiratory responses to carotid sinus pressure alteration in experimental hypertension.
Hemodynamic and respiratory responses to carotid sinus pressure alteration in experimental hypertension.
复制标题
实验性高血压中颈动脉窦压力变化的血流动力学和呼吸反应。
DOI：
10.1152/jappl.1993.74.3.1274
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Kligman,MD
中科院分区：
文献类型：
--
作者：
Brunner,MJ;Kligman,MD
这项研究的目的是确定压力感受性反射对呼吸反应的控制是否在高血压患者中减弱。10只犬采用双侧肾包绕法制作慢性高血压模型。8只假手术狗作为正常血压对照。在实验性高血压形成后，颈动脉压力感受性反射对动脉压、心率、呼吸频率、潮气量和通气量的控制进行了尖锐的评估。在戊巴比妥麻醉和双侧迷走神经切断术下，分离颈动脉窦并在控制压力下进行灌流。在操作颈动脉窦区之前，高血压组的平均动脉压(146.4±2.3毫米汞柱)显著高于正常血压组(124.7±2.6毫米汞柱)(P<；0.005)。高血压组各水平颈动脉窦压力测得的平均动脉压和心率均显著高于高血压组。高血压组的心率反射增益显著降低，但平均动脉压未见明显降低。呼吸频率、潮气量和对颈动脉窦压力变化的呼吸反应显著，导致大约40%的呼吸反射改变。高血压组的这些反应并未减弱。我们的结论是，呼吸压力感受性反射反应在实验性高血压中得以保留。
The purpose of this study was to determine whether baroreflex control of respiratory responses is diminished in hypertension. Ten dogs were made chronically hypertensive with use of a bilateral renal wrap technique. Eight sham-operated dogs served as normotensive controls. After the development of experimental hypertension, carotid baroreflex control of arterial pressure, heart rate, respiratory frequency, tidal volume, and ventilation was acutely assessed. Under pentobarbital anesthesia and with bilateral vagotomy, the carotid sinuses were isolated and perfused at controlled pressures. Before the carotid sinus region was manipulated, the mean arterial pressure was significantly higher (P < 0.005) in the hypertensive group (146.4 +/- 2.3 mmHg) than in the normotensive group (124.7 +/- 2.6 mmHg). The mean arterial pressures and heart rates measured at every level of carotid sinus pressure were significantly higher in the hypertensive group. Reflex gain of heart rate, but not mean arterial pressure, was significantly reduced in the hypertensive group. Respiratory frequency, tidal volume, and ventilatory responses to changes in carotid sinus pressure were significant and resulted in an approximately 40% reflex change in ventilation. These responses were not diminished in the hypertensive group. We conclude that respiratory baroreflex responses are preserved in experimental hypertension.
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