Maximum vasoactive-inotropic score and mortality in extremely premature, extremely low birth weight infants.
Maximum vasoactive-inotropic score and mortality in extremely premature, extremely low birth weight infants.
复制标题
在极早，极低的出生体重婴儿中，最大的血管活性 - 触发性评分和死亡率。
DOI：
10.1038/s41372-021-01030-9
复制
发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
de la Cruz D
中科院分区：
文献类型：
--
作者：
Aziz KB;Lavilla OC;Wynn JL;Lure AC;Gipson D;de la Cruz D
确定极早产儿（小于29孕周）、极低出生体重儿（小于1000 g）的最大血管收缩力（VISmax）与死亡率之间的关系。单中心、回顾性、观察性队列研究。我们确定了436个ELBW，<29周，在研究期间照顾的先天性婴儿。与VISmax为0的婴儿相比，基于VISmax的死亡率为3.3倍至46.1倍。VISmax >30与普遍死亡率相关。包括胎龄、出生体重和VISmax的多变量建模显示，在接受血管活性变力治疗的患者中，阴性预测值为87.0%，阳性预测值为84.8% [校正AUROC：0.90，（0.86-0.94）]，对预测死亡率具有显著效用。VISmax是血流动力学/心血管支持的客观指标，与极早产ELBW婴儿的死亡率直接相关。VISmax代表了新生儿精准医疗和极早产ELBW婴儿风险分层的重要一步。
To determine the relationship between maximum vasoactive-inotropic (VISmax) and mortality in extremely premature (<29 weeks completed gestation), extremely low birth weight (ELBW, <1000 grams) infants. Single-center, retrospective, observational cohort study. We identified 436 ELBW, <29 week, inborn infants cared for during the study period. Compared to infants with VISmax of 0, the frequency of mortality based on VISmax ranged from 3.3-fold to 46.1 fold. VISmax >30 was associated with universal mortality. Multivariable modeling that included gestational age, birth weight, and VISmax revealed significant utility to predict mortality with negative predictive value of 87.0% and positive predictive value of 84.8% [adjusted AUROC: 0.90, (0.86-0.94)] among patients that received vasoactive-inotropic treatment. VISmax is an objective measure of hemodynamic/cardiovascular support that was directly associated with mortality in extremely premature ELBW infants. The VISmax represents an important step towards neonatal precision medicine and risk-stratification of extremely premature ELBW infants.
登录
查看更多内容
影响因子：
4.1
作者：
Gaies, Michael G.;Gurney, James G.;Hirsch, Jennifer C.
通讯作者：
Hirsch, Jennifer C.
影响因子：
2.1
作者：
Dempsey, E. M.;Barrington, K. J.
通讯作者：
Barrington, K. J.
影响因子：
2.1
作者：
EI-Khuffash, Afif;McNamara, Patrick J.
通讯作者：
McNamara, Patrick J.
影响因子：
3
作者：
El-Khuffash, Afif F.;McNamara, Patrick J.
通讯作者：
McNamara, Patrick J.
影响因子：
8
作者：
Lee, SK;McMillan, DD;Sale, J
通讯作者：
Sale, J