K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.
K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.
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DOI：
10.1038/nn.3185
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发表时间：
2012-09
影响因子：
25
通讯作者：
Roeper, Jochen
中科院分区：
文献类型：
--
作者：
Schiemann, Julia;Schlaudraff, Falk;Klose, Verena;Bingmer, Markus;Seino, Susumu;Magill, Peter J.;Zaghloul, Kareem A.;Schneider, Gaby;Liss, Birgit;Roeper, Jochen
中脑多巴胺（DA）系统对意外奖励或新奇事物的时相激活对适应性行为策略至关重要。DA中脑神经元的这种激活通过从低频背景尖峰到瞬时高频突发放电的突触触发开关发生。我们发现，在黑质（SN）的内侧DA神经元，ATP敏感性钾（K-ATP）通道的活动，使NMDA介导的爆发在体外以及在体内自发的爆发放电在麻醉小鼠。细胞选择性沉默内侧SN DA神经元中的K-ATP通道活性揭示了它们的K-ATP通道门控爆发放电对于新奇依赖性探索行为至关重要。我们还检测到K-ATP通道和NMDA受体亚基的转录上调，以及高的体内爆发放电，在存活的SN DA神经元从帕金森病患者，这表明爆发门控K-ATP通道功能在DA神经元影响疾病和健康的表型。
Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found that, in medial DA neurons of the substantia nigra (SN), activity of ATP-sensitive potassium (K-ATP) channels enabled NMDA-mediated bursting in vitro as well as spontaneous in vivo burst firing in anesthetized mice. Cell-selective silencing of K-ATP channel activity in medial SN DA neurons revealed that their K-ATP channel-gated burst firing was crucial for novelty-dependent exploratory behavior. We also detected a transcriptional upregulation of K-ATP channel and NMDA receptor subunits, as well as high in vivo burst firing, in surviving SN DA neurons from Parkinson’s disease patients, suggesting that burst-gating K-ATP channel function in DA neurons affects phenotypes in both disease and health.
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通过基础神经节电路的光遗传控制对帕金森运动行为的调节。
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1523/jneurosci.3890-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrews ZB;Erion D;Beiler R;Liu ZW;Abizaid A;Zigman J;Elsworth JD;Savitt JM;DiMarchi R;Tschoep M;Roth RH;Gao XB;Horvath TL
通讯作者：
Horvath TL
影响因子：
14.5
作者：
Bodi, Nikoletta;Keri, Szabolcs;Gluck, Mark A.
通讯作者：
Gluck, Mark A.
DOI：
10.1152/ajpendo.00262.2010
发表时间：
2011-02-01
影响因子：
5.1
作者：
Geng, Xuehui;Lou, Haiyan;Drain, Peter
通讯作者：
Drain, Peter
影响因子：
2.9
作者：
Deacon, RMJ;Brook, RC;Liss, B
通讯作者：
Liss, B