Preparation, applications, and challenges of functional DNA nanomaterials.

Preparation, applications, and challenges of functional DNA nanomaterials.
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功能性DNA纳米材料的制备、应用及挑战

DOI:
10.1007/s12274-022-4793-5
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发表时间:
2023
期刊:
影响因子:
9.9
通讯作者:
--
中科院分区:
材料科学1区
文献类型:
--
作者:

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作为遗传信息的载体,DNA是制造纳米结构和纳米器件的通用模块。功能分子可以通过精确的碱基互补配对整合到DNA中,极大地扩展了DNA纳米材料的功能。这些功能赋予了DNA纳米材料在生物医学领域的巨大应用潜力。近年来,功能性DNA纳米材料得到了迅速的研究和完善。已有文献从功能的角度对DNA纳米材料进行了分类,本文主要介绍了功能性DNA纳米材料的制备方法。本文综述了具有分子识别、纳米酶催化、药物传递、生物医用材料模板等功能的DNA纳米材料的制备方法。然后,系统地综述了功能性DNA纳米材料的最新应用进展。最后,对功能性DNA纳米材料的研究现状和前景进行了展望。
As a carrier of genetic information, DNA is a versatile module for fabricating nanostructures and nanodevices. Functional molecules could be integrated into DNA by precise base complementary pairing, greatly expanding the functions of DNA nanomaterials. These functions endow DNA nanomaterials with great potential in the application of biomedical field. In recent years, functional DNA nanomaterials have been rapidly investigated and perfected. There have been reviews that classified DNA nanomaterials from the perspective of functions, while this review primarily focuses on the preparation methods of functional DNA nanomaterials. This review comprehensively introduces the preparation methods of DNA nanomaterials with functions such as molecular recognition, nanozyme catalysis, drug delivery, and biomedical material templates. Then, the latest application progress of functional DNA nanomaterials is systematically reviewed. Finally, current challenges and future prospects for functional DNA nanomaterials are discussed.
纳米颗粒上层建筑的DNA组装,用于受控生物递送和消除。
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