Obesity Management in Cardiometabolic Disease: State of the Art.
Obesity Management in Cardiometabolic Disease: State of the Art.
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DOI：
10.1007/s11883-021-00953-0
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发表时间：
2021-08-04
影响因子：
5.8
通讯作者：
Cornier MA
中科院分区：
文献类型：
--
作者：
Iwamoto SJ;Abushamat LA;Zaman A;Millard AJ;Cornier MA
总结过去5年来关于减肥治疗（包括生活方式改变、抗肥胖药物和减肥手术）对成人心血管疾病（CVD）风险因素和CVD结局影响的研究。这篇叙述性综述包括并总结了这些不同减肥方法的影响的当代证据。使用关键词肥胖、体重减轻、CVD、心脏代谢和风险因素进行文献检索，并纳入过去5年的关键临床试验。通过减肥进行的肥胖管理与CVD风险因素的改善相关，如血压、血脂和血糖控制的改善，更大的减肥导致CVD风险因素的更大改善。减肥手术与其他肥胖手术和治疗相比，与更大的体重减轻相关，因此，也可能出于其他原因，它与CVD结局和死亡率的更大降低相关。肥胖是一个独立的危险因素和其他CVD危险因素的调节剂，因此，肥胖的治疗应该是降低CVD风险的管理策略的组成部分。未来需要更长时间的试验和真实世界研究，以告知提供者和患者如何通过肥胖管理来个体化改变心脏代谢疾病风险的方法。
To summarize research from the last 5 years on the effects of weight loss treatments, including lifestyle changes, anti-obesity medications, and bariatric procedures on cardiovascular disease (CVD) risk factors and CVD outcomes in adults. This narrative review includes and summarizes the contemporary evidence of the effects of these different weight loss approaches individually. A literature search was performed using the key words obesity, weight loss, CVD, cardiometabolic, and risk factors and included key clinical trials from the past 5 years. Obesity management through weight loss is associated with improvements in CVD risk factors, such as improved blood pressure, lipid profiles, and glycemic control, with greater weight loss leading to greater improvements in CVD risk factors. Bariatric surgery is associated with greater weight loss than the other procedures and treatments for obesity, and for this, and possibly for other reasons, it is associated with greater reductions in CVD outcomes and mortality. Obesity is an independent risk factor and modulator of other CVD risk factors, and thus, treatment of obesity should be an integral part of management strategies to reduce CVD risk. Future trials and real-world studies of longer duration are needed to inform providers and patients on how to individualize the approach to modifying risks of cardiometabolic disorders through obesity management.
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DOI：
10.1038/ijo.2011.158
发表时间：
2012-06
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Astrup A;Carraro R;Finer N;Harper A;Kunesova M;Lean ME;Niskanen L;Rasmussen MF;Rissanen A;Rössner S;Savolainen MJ;Van Gaal L;NN8022-1807 Investigators
通讯作者：
NN8022-1807 Investigators
影响因子：
16.9
作者：
Courcoulas, Anita P.;King, Wendy C.;Yanovski, Susan Z.
通讯作者：
Yanovski, Susan Z.
影响因子：
120.7
作者：
Gardner, Christopher D.;Trepanowski, John F.;King, Abby C.
通讯作者：
King, Abby C.
影响因子：
5.4
作者：
Benotti PN;Wood GC;Carey DJ;Mehra VC;Mirshahi T;Lent MR;Petrick AT;Still C;Gerhard GS;Hirsch AG
通讯作者：
Hirsch AG
在前面的研究中，适应性超出体重减轻的影响对2型糖尿病患者的心血管危险因素的影响。
影响因子：
8.3
作者：
Gibbs BB;Brancati FL;Chen H;Coday M;Jakicic JM;Lewis CE;Stewart KJ;Clark JM;(for the Look AHEAD Research Group)
通讯作者：
(for the Look AHEAD Research Group)