Effect of improved fitness beyond weight loss on cardiovascular risk factors in individuals with type 2 diabetes in the Look AHEAD study.
Effect of improved fitness beyond weight loss on cardiovascular risk factors in individuals with type 2 diabetes in the Look AHEAD study.
复制标题
在前面的研究中，适应性超出体重减轻的影响对2型糖尿病患者的心血管危险因素的影响。
DOI：
10.1177/2047487312462823
复制
发表时间：
2014-05
影响因子：
8.3
通讯作者：
(for the Look AHEAD Research Group)
中科院分区：
文献类型：
--
作者：
Gibbs BB;Brancati FL;Chen H;Coday M;Jakicic JM;Lewis CE;Stewart KJ;Clark JM;(for the Look AHEAD Research Group)
由于生活方式引起的心血管危险因素的改善在2型糖尿病患者中差异很大，我们调查了健身增加在多大程度上解释了心血管危险因素的改善，而不依赖于生活方式干预中的体重减轻。我们研究了Look AHEAD的1年变化，这是一项随机试验，比较了2型糖尿病成人患者的强化生活方式干预（ILI）与糖尿病支持和教育对照组（DSE）。评估包括体重、健身、血压（BP）、血糖、HbA 1c和血脂。我们使用多元线性回归的R2，评估了体重和健康状况的变化对研究组心血管危险因素变化的影响。分析包括在基线和1年时具有健身数据的参与者（n= 4，408; 41%男性，36%非白人，平均年龄58.7± 6.8岁）。体重变化单独改善R2解释ILI中高达8.2%和DSE中高达1.7%的风险因素变化。ILI和DSE中，仅健身改变就将R2提高了3.9%和0.8%。调整体重变化后，健身与ILI中葡萄糖（+0.7%）、HbA 1c（+1.1%）、HDL胆固醇（+0.4%）和甘油三酯（+0.2%）的R2改善以及DSE中DBP（+0.3%）、葡萄糖（+0.3%）、HbA 1c（+0.4%）和甘油三酯（+0.1%）的R2改善独立相关（p<0.05）。总的来说，体重和健康的变化解释了心血管危险因素变化的0.1-9.3%。健身的增加解释了除了减肥之外的几个心血管风险因素的统计学显著但微小的改善。需要进一步研究确定解释心血管危险因素变化的其他因素。
Because lifestyle-induced improvements in cardiovascular risk factors vary substantially across individuals with type 2 diabetes, we investigated the extent to which increases in fitness explain cardiovascular risk factor improvements independent of weight loss in a lifestyle intervention. We studied 1-year changes in Look AHEAD, a randomized trial comparing an intensive lifestyle intervention (ILI) to a diabetes support and education control group (DSE) in adults with type 2 diabetes. Assessments included weight, fitness, blood pressure (BP), glucose, HbA1c, and lipids. We evaluated the effects of changes in weight and fitness on changes in cardiovascular risk factors by study arm, using R2 from multiple linear regression. Analyses included participants with fitness data at baseline and 1-year (n=4,408; 41% male, 36% non-White, mean age 58.7± 6.8 years). Weight change alone improved R2 for explaining changes in risk factors up to 8.2% in ILI and 1.7% in DSE. Fitness change alone improved R2 up to 3.9% in ILI and 0.8% in DSE. After adjusting for weight change, fitness was independently associated (p<0.05) with improvements in R2 for glucose (+0.7%), HbA1c (+1.1 %), HDL cholesterol (+0.4%) and triglycerides (+0.2%) in ILI and DBP (+0.3%), glucose (+0.3%), HbA1c (+0.4%), and triglycerides (+0.1%) in DSE. Taken together, weight and fitness changes explained from 0.1–9.3% of the variability in cardiovascular risk factor changes. Increased fitness explained statistically significant but small improvements in several cardiovascular risk factors beyond weight loss. Further research identifying other factors that explain cardiovascular risk factor change is needed.
登录
查看更多内容
影响因子：
120.7
作者：
Blumenthal, JA;Sherwood, A;Hinderliter, A
通讯作者：
Hinderliter, A
影响因子：
4.9
作者：
Jakicic, J. M.;Jaramillo, S. A.;Balasubramanyam, A.;Bancroft, B.;Curtis, J. M.;Mathews, A.;Pereira, M.;Regensteiner, J. G.;Ribisl, P. M.
通讯作者：
Ribisl, P. M.
影响因子：
8.2
作者：
Boulé, NG;Kenny, GP;Sigal, RJ
通讯作者：
Sigal, RJ
影响因子：
4.8
作者：
Taylor, C. Barr;Conrad, Ansgar;Spiegel, David
通讯作者：
Spiegel, David
DOI：
10.1016/j.numecd.2009.04.015
发表时间：
2010-10-01
影响因子：
3.9
作者：
Balducci, S.;Zanuso, S.;Pugliese, G.
通讯作者：
Pugliese, G.