Lifestyle-mediated nitric oxide boost to prevent SARS-CoV-2 infection: A perspective.
Lifestyle-mediated nitric oxide boost to prevent SARS-CoV-2 infection: A perspective.
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DOI：
10.1016/j.niox.2021.08.001
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发表时间：
2021-10-01
期刊：
影响因子：
--
通讯作者：
Kobayashi J
中科院分区：
文献类型：
--
作者：
Kobayashi J
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）已在世界范围内传播，并造成严重的发病率和死亡率，严重威胁公共卫生。冠状病毒病（COVID-19）患者因衰老、糖尿病、高血压和肥胖而存在内皮功能障碍，这是危及生命的血栓栓塞并发症的高风险。这表明内皮细胞一氧化氮（NO）生成和NO生物利用度降低可能是COVID-19进展的共同潜在病理。越来越多的关于SARS-CoV-2感染的实验和临床研究证据表明，NO抑制COVID-19的发病机制，包括病毒进入宿主细胞、病毒复制、宿主免疫反应和随后的血栓栓塞并发症。恢复一氧化氮的生物利用度可能成为COVID-19的预防或早期治疗选择。本综述旨在深入讨论NO的生物利用度，以预防SARS-CoV-2感染，特别是通过关注生活方式因素，如富含硝酸盐的饮食、体育锻炼和鼻腔呼吸，这些都可以很容易地每天进行，以提高NO的生物利用度。
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide and has seriously threatened public health by causing significant morbidity and mortality. Patients with coronavirus disease (COVID-19) with preexisting endothelial dysfunction caused by aging, diabetes, hypertension, and obesity are at high risk for life-threatening thromboembolic complications. This suggests a possibility that reduced endothelial nitric oxide (NO) production and NO bioavailability could be a common underlying pathology for the progression of COVID-19. Increasingly, evidence from experimental and clinical studies of SARS-CoV-2 infection shows that NO inhibits the pathogenesis of COVID-19, including virus entry into host cells, viral replication, host immune response, and subsequent thromboembolic complications. Restoring NO bioavailability may have the potential to be a preventive or early-treatment option for COVID-19. This review aims to provide in-depth discussion of NO bioavailability to prevent SARS-CoV-2 infection, particularly by focusing on lifestyle factors such as nitrate-rich diets, physical exercise, and nasal breathing, which could be easily performed on a daily basis to boost NO bioavailability.
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