Vitreous Findings by Handheld Spectral-Domain OCT Correlate with Retinopathy of Prematurity Severity.
Vitreous Findings by Handheld Spectral-Domain OCT Correlate with Retinopathy of Prematurity Severity.
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DOI：
10.1016/j.oret.2020.03.027
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Cabrera MT
中科院分区：
文献类型：
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作者：
Legocki AT;Zepeda EM;Gillette TB;Grant LE;Shariff A;Touch P;Lee AY;Ding L;Estrada MM;Tarczy-Hornoch K;Lee CS;Mayock DE;Pepple KL;Cabrera MT
评估手持式光谱域光学相干断层扫描检测早产儿视网膜病变与玻璃体病变之间的关系。前瞻性、观察性队列研究。2015年7月至2018年3月期间，在两家学术新生儿重症监护病房连续抽取92名早产儿进行视网膜病变筛查。婴儿在常规早产儿视网膜病变检查时进行手持式光谱域光学相干断层扫描。两名蒙面、训练有素的评分员分析了右眼玻璃体视网膜的发现，包括5次中央凹/中央凹旁b片点状高反射玻璃体混浊的半自动量化（玻璃体混浊比）。排除治疗后的数据，玻璃体检查结果与临床早产儿视网膜病变诊断进行比较。图像分级者对所有玻璃体视网膜发现的一致性为91% （kappa=0.86[95%可信区间，0.82-0.90]，P<0.001）。在接受280次影像学检查的92名婴儿中（52%为男性，平均胎龄28.3±2.8周，平均出生体重1014.5±285.0克），36/92（39%）发生早产儿视网膜病变。在61/92（66%）的婴儿中发现点状高反射性玻璃体混浊。至少一次出现点状高反射性玻璃体混浊与以下诊断相关：早产儿视网膜病变（62%对29%，无混浊，P=0.003）、早产儿视网膜病变严重程度（P=0.001）、前期或前期病变（24%对5%，P=0.005）和1型病变（14%对2%，P=0.03）。29例（45次影像学检查）右眼点状高反射性玻璃体混浊患儿中，两级评分玻璃体混浊比（F1分0.82±0.36，Dice系数0.97±0.04）与早产儿视网膜病变相关（P=0.02）。牵拉性玻璃体带与阳性疾病相关（29% vs. 5%无带，P=0.05）。点状高反射性玻璃体混浊和牵拉性玻璃体带预测早产儿视网膜病变的存在和严重程度。进一步的研究应该探索手持式光学相干断层扫描作为一种非侵入性的早产儿视网膜病变筛查工具。
To evaluate the association between retinopathy of prematurity and vitreous findings in premature infants detected by handheld spectral-domain optical coherence tomography. Prospective, observational cohort study. Consecutive sample of 92 premature infants requiring retinopathy of prematurity screening at two academic neonatal intensive care units, between July 2015 and March 2018. Infants underwent handheld spectral domain optical coherence tomography at the time of routine retinopathy of prematurity examinations. Two masked, trained graders analyzed right eye vitreoretinal findings including semi-automated quantification of punctate hyperreflective vitreous opacities within 5 foveal/parafoveal B-scans (Vitreous Opacity Ratio). Excluding post-treatment data, vitreous findings were compared to clinical retinopathy of prematurity diagnoses. Agreement between image graders for all vitreoretinal findings was 91% (kappa=0.86 [95% confidence interval, 0.82–0.90], P<0.001). Among 92 infants undergoing 280 imaging sessions (52% male, mean gestational age 28.3±2.8 weeks, mean birthweight 1014.5±285.0 grams), 36/92 (39%) developed retinopathy of prematurity. Punctate hyperreflective vitreous opacities were identified in 61/92 (66%) infants. The presence of punctate hyperreflective vitreous opacities at least once was associated with a diagnosis of retinopathy of prematurity (62% vs. 29% without opacities, P=0.003), maximum retinopathy of prematurity stage (P=0.001), pre-plus or plus disease (24% vs. 5%, P=0.005), and type 1 disease (14% vs. 2%, P=0.03). Among 29 infants (45 imaging sessions) with right eye punctate hyperreflective vitreous opacities, the Vitreous Opacity Ratio from two graders (F1 score 0.82±0.36, Dice coefficient 0.97±0.04) correlated with retinopathy of prematurity stage (P=0.02). Tractional vitreous bands on imaging correlated with plus disease status (29% vs. 5% without bands, P=0.05). Punctate hyperreflective vitreous opacities and tractional vitreous bands predict the presence and severity of retinopathy of prematurity. Further studies should explore handheld optical coherence tomography as a non-invasive retinopathy of prematurity screening tool.
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影响因子：
--
作者：
Cabrera, Michelle T.;O'Connell, Rachelle V.;Freedman, Sharon F.
通讯作者：
Freedman, Sharon F.
影响因子：
4.4
作者：
Vinekar, Anand;Avadhani, Kavitha;Shetty, Bhujang K.
通讯作者：
Shetty, Bhujang K.
影响因子：
--
作者：
Muni, Rajeev H.;Kohly, Radha P.;Lee, Thomas C.
通讯作者：
Lee, Thomas C.
影响因子：
--
作者：
Saunders, RA;Donahue, ML;Phelps, DL
通讯作者：
Phelps, DL
影响因子：
4.1
作者：
Richardson, PRS;Boulton, ME;McLeod, D
通讯作者：
McLeod, D