Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?
Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?
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HSV-1感染诱导的小胶质细胞免疫反应在中枢神经系统疾病中的作用：朋友还是敌人？
DOI：
10.1080/1040841x.2019.1660615
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发表时间：
2019-09
影响因子：
6.5
通讯作者：
Yifei Wang
中科院分区：
文献类型：
--
作者：
Yiliang Wang;Jiaoyan Jia;Yun Wang;Feng Li;Xiaowei Song;Shurong Qin;Zhaoyang Wang;Kaio Kitazato;Yifei Wang
摘要小胶质细胞作为脑内的巨噬细胞，是机体抵御病原体入侵的第一道防线。此外，人们已认识到它们的功能障碍与日益严重的中枢神经系统疾病密切相关。值得注意的是，慢性HSV-1感染导致小胶质细胞的持续活化，其通过产生具有神经毒性和神经保护作用的某些因子引起全面反应。HSV-1的CNS感染导致单纯疱疹病毒性脑炎和单纯疱疹病毒性角膜炎。小胶质细胞免疫反应在这些疾病的发生发展中起着至关重要的作用。此外，HSV-1感染与几种CNS疾病，特别是阿尔茨海默病和精神分裂症密切相关。这些CNS疾病可以通过引发适当的免疫应答（例如抑制小胶质细胞增殖和活化）来有效地改善。因此，重新评估小胶质细胞在HSV-1 CNS感染中的积极和消极作用对于更全面和详细地了解小胶质细胞与CNS疾病的关系至关重要。因此，本综述的重点是小胶质细胞介导HSV-1 CNS感染的双重作用，以及针对小胶质细胞改善CNS疾病的策略。该领域的深入研究有助于全面阐明小胶质细胞免疫应答在HSV-1 CNS感染中的双重作用，为寻找CNS疾病中小胶质细胞过度活跃和HSV-1感染的治疗靶点提供理论基础。
Abstract Microglia, as brain-resident macrophages, are the first line of defense against brain invading pathogens. Further, their dysfunction has been recognized to be closely associated with mounting CNS diseases. Of note, chronic HSV-1 infection leads to the persistent activation of microglia, which elicit a comprehensive response by generating certain factors with neurotoxic and neuroprotective effects. CNS infection with HSV-1 results in herpes simplex encephalitis and herpes simplex keratitis. Microglial immune response plays a crucial role in the development of these diseases. Moreover, HSV-1 infection is strongly associated with several CNS diseases, especially Alzheimer’s disease and schizophrenia. These CNS diseases can be effectively ameliorated by eliciting an appropriate immune response, such as inhibition of microglial proliferation and activation. Therefore, it is crucial to reassess the positive and negative roles of microglia in HSV-1 CNS infection for a more comprehensive and detailed understanding of the relationship between microglia and CNS diseases. Hence, the present review focuses on the dual roles of microglia in mediating HSV-1 CNS infection, as well as on the strategy of targeting microglia to ameliorate CNS diseases. Further research in this field can help comprehensively elucidate the dual role of the microglial immune response in HSV-1 CNS infection, providing a theoretical basis for identifying therapeutic targets against overactive microglia in CNS diseases and HSV-1 infection.
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影响因子：
4.5
作者：
Kato, Takahiro;Monji, Akira;Kanba, Shigenobu
通讯作者：
Kanba, Shigenobu
影响因子：
29.7
作者：
Davis BK;Wen H;Ting JP
通讯作者：
Ting JP
影响因子：
7.3
作者：
Wang Y;Wang Z;Wang Y;Li F;Jia J;Song X;Qin S;Wang R;Jin F;Kitazato K;Wang Y
通讯作者：
Wang Y
I型干扰素介导的单基因自身炎症：I型干扰素病，概念概述。
DOI：
10.1084/jem.20161596
发表时间：
2016-11-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Rodero MP;Crow YJ
通讯作者：
Crow YJ
影响因子：
64.8
作者：
通讯作者：
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