Time-dependent changes in the clinical characteristics and prognosis of hospitalized COVID-19 patients in Wuhan, China: A retrospective study.
Time-dependent changes in the clinical characteristics and prognosis of hospitalized COVID-19 patients in Wuhan, China: A retrospective study.
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DOI：
10.1016/j.cca.2020.06.051
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Wan J
中科院分区：
文献类型：
--
作者：
Wang M;Zhang J;Ye D;Wang Z;Liu J;He H;Shen B;Luo Z;Ye J;Xu Y;Zhao M;Liu M;Zhang P;Gu J;Pan W;Liu M;Li D;Wan J
最近，2019 年冠状病毒病（COVID-19）病例在世界各地爆发。然而，COVID-19患者临床症状和预后的动态变化仍不清楚。根据初始临床症状的出现时间，2020年1月22日至2月14日期间收治的843例COVID-19患者分为三组：A组（1月21日至1月25日，n=324）、B组（1月26日至1月31日，n=358）和C组（2月1日至2月10日，n=161）。收集有关人口统计、症状、首次实验室结果、治疗和结果（住院 12 天内）的数据。结果显示，从症状出现到入院的中位持续时间随着时间的推移而缩短（分别为 13 天、10 天和 5 天，p < 0.05）。与A、B组相比，C组出现发热症状和双侧肺炎的患者较少。实验室结果显示，C组白细胞、中性粒细胞、血小板计数、乳酸、D-二聚体水平较低，淋巴细胞、CD3、CD8计数较高。此外，C组轻中度病例较多，重症病例较少。更重要的是，并发症的发生率（分别为 18.5%、14.2% 和 11.2%，p < 0.05）和全因死亡率（分别为 11.7%、8.4% 和 5.6%，p < 0.05）随着时间的推移而下降。 COVID-19患者的临床特征和预后随着时间的推移而变化。在后期发现预后有所改善。
Cases of coronavirus disease 2019 (COVID-19) have been breaking out around the world recently. However, the dynamic changes in the clinical symptoms and prognosis of COVID-19 patients remain unknown. According to the onset time of initial clinical symptoms, 843 COVID-19 patients admitted between Jan 22 and Feb 14, 2020 were divided into three groups: group A (Jan 21 to Jan 25, n = 324), group B (Jan 26 to Jan 31, n = 358) and group C (Feb 1 to Feb 10, n = 161). Data on the demographics, symptoms, first laboratory results, treatments and outcomes (within 12 days of hospitalization) were collected. The results showed that the median duration from symptom onset to admission shortened over time (13, 10 and 5 days, respectively, p < 0.05). Fewer patients had fever symptoms and bilateral pneumonia in group C than in the group A and B. Laboratory results showed that white blood cell, neutrophil, and platelet counts, lactic acid and D-dimer levels were lower, while lymphocyte, CD3, and CD8 counts were higher in group C. In addition, group C had more mild-moderate cases and fewer severe cases than the other two groups. More importantly, the incidence of complications (18.5%, 14.2% and 11.2%, respectively, p < 0.05) and all-cause mortality (11.7%, 8.4%, and 5.6%, respectively, p < 0.05) decreased over time. The clinical characteristics and prognosis of COVID-19 patients changed over time. Improved prognosis was found at a later stage.
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影响因子：
39
作者：
Lowe, Dylan A.;Wu, Nancy;Weiss, Ethan J.
通讯作者：
Weiss, Ethan J.
影响因子：
6.7
作者：
Li, Kunhua;Wu, Jiong;Li, Chuanming
通讯作者：
Li, Chuanming
DOI：
10.1016/s0140-6736(03)13410-1
发表时间：
2003-05-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Donnelly CA;Ghani AC;Leung GM;Hedley AJ;Fraser C;Riley S;Abu-Raddad LJ;Ho LM;Thach TQ;Chau P;Chan KP;Lam TH;Tse LY;Tsang T;Liu SH;Kong JH;Lau EM;Ferguson NM;Anderson RM
通讯作者：
Anderson RM
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影响因子：
120.7
作者：
Wang, Dawei;Hu, Bo;Peng, Zhiyong
通讯作者：
Peng, Zhiyong
影响因子：
120.7
作者：
Pan, An;Liu, Li;Wu, Tangchun
通讯作者：
Wu, Tangchun