Silver chalcogenide nanoparticles: a review of their biomedical applications.

Silver chalcogenide nanoparticles: a review of their biomedical applications.
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硫属银纳米粒子:其生物医学应用综述

DOI:
10.1039/d0nr03872e
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发表时间:
2021-12-02
期刊:
影响因子:
6.7
通讯作者:
Cormode DP
Cormode DP
中科院分区:
材料科学2区
文献类型:
--
作者:
Nieves LM;Mossburg K;Hsu JC;Maidment ADA;Cormode DP

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硫属银化物(Ag₂X,其中X = S、Se或Te)纳米粒子因其在电子学中的应用已被广泛研究,但直到最近才在生物医学应用方面进行探索。在过去10年中,Ag₂X(最初主要是硫化银)作为量子点变得非常重要,因为它们不仅在近红外一区和二区具有出色的深层组织成像特性,而且毒性较低。它们的这些吸引人的特性促使近期Ag₂X在生物医学应用方面有了大量的发展。此外,在过去2 - 3年中发现Ag₂X是有效的X射线造影剂,这增加了这些纳米粒子在生物医学方面的众多用途。在这篇综述中,我们讨论了硫属银化物纳米粒子在生物成像、诊疗一体化和生物传感器等领域的最新进展。此外,我们研究了这些纳米粒子的合成方法的进展,包括水相和有机合成路线。最后,我们讨论了硫属银化物在不同生物医学应用中的优势和当前的局限性,以及它们在使用方面进一步发展和扩展的潜力。
Silver chalcogenide (Ag2X, where X = S, Se, or Te) nanoparticles have been extensively investigated for their applications in electronics but have only recently been explored for biomedical applications. In the past 10 years, Ag2X, primarily silver sulfides at first, have become of great importance as quantum dots, since they not only possess excellent deep tissue imaging properties in the near-infrared regions I and II, but also have low toxicities. Their appealing properties have led to numerous recent developments of Ag2X for biomedical applications. Furthermore, Ag2X have been discovered in the past 2–3 years to be potent X-ray contrast agents, adding to the numerous biomedical uses of these nanoparticles. In this review, we discuss the most recent advances in silver chalcogenide nanoparticle use in areas such as bioimaging, theranostics, and biosensors. Moreover, we examine the advances in synthetic approaches for these nanoparticles, which include aqueous and organic syntheses routes. Finally, we discuss the advantages and current limitations in the use of silver chalcogenides for different biomedical applications and their potential for advancement and expansions in use.
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