Effect of a modified, well-tolerated niacin regimen on serum total cholesterol, high density lipoprotein cholesterol and the cholesterol to high density lipoprotein ratio.
Effect of a modified, well-tolerated niacin regimen on serum total cholesterol, high density lipoprotein cholesterol and the cholesterol to high density lipoprotein ratio.
复制标题
改良的、耐受性良好的烟酸疗法对血清总胆固醇、高密度脂蛋白胆固醇以及胆固醇与高密度脂蛋白比率的影响。
DOI：
10.1016/0002-9149(89)90754-6
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
W. Grossman
中科院分区：
文献类型：
--
作者：
J. Alderman;J. Alderman;J. Alderman;R. Pasternak;R. Pasternak;R. Pasternak;F. Sacks;F. Sacks;F. Sacks;H. S. Smith;H. S. Smith;H. S. Smith;E. Monrad;E. Monrad;E. Monrad;W. Grossman;W. Grossman;W. Grossman
对101例总胆固醇与高密度脂蛋白（HDL）胆固醇的预处理比值>4.0的冠心病患者进行烟酸治疗，从低剂量（100 - 250 mg，每日两次）开始，在4 - 8周内逐渐增加剂量至1,000 mg，每日两次。调整剂量以尽量减少副作用。平均随访时间为11 ± 7个月，平均剂量为1，415 ± 698 mg/天，该组总胆固醇降低13%，HDL升高31%，胆固醇与HDL比值降低32%。一个由62名患者组成的亚组，每天服用>1,000 mg烟酸，总胆固醇降低18%，HDL升高32%，胆固醇与HDL比率改善36%。一个亚组的39名患者服用<1,000毫克/天的烟酸只有5%的总胆固醇降低，但HDL增加29%，胆固醇与HDL的比例降低24%。38%的患者报告了烟酸的副作用，但仅4例导致治疗中断。烟酸可以以一种耐受性良好、价格低廉且在改善胆固醇与HDL比率方面非常有效的方式给药。
One hundred one patients with coronary artery disease and pretreatment ratios of total cholesterol to high density lipoprotein (HDL) cholesterol >4.0 were treated with niacin, commencing at low dosages (100 to 250 mg twice daily) and gradually increasing the dosage over 4 to 8 weeks to 1,000 mg twice daily. Dosage adjustments were made to minimize side effects. At a mean follow-up duration of 11 ± 7 months, and a mean dosage of 1,415 ± 698 mg/day, the group had a 13% reduction in total cholesterol, 31% increase in HDL and 32% decrease in the cholesterol to HDL ratio. A subgroup of 62 patients taking >1,000 mg/day of niacin had an 18% reduction in total cholesterol, 32% increase in HDL and 36% improvement in the cholesterol to HDL ratio. A subgroup of 39 patients taking <1,000 mg/day of niacin had only a 5% reduction in total cholesterol, although a 29% increase in HDL and a 24% decrease in the cholesterol to HDL ratio were recorded. Side effects of niacin were reported in 38% of the patients, but led to discontinuation of therapy in only 4. Niacin can be administered in a fashion that is well tolerated, inexpensive and very effective in improving the cholesterol to HDL ratio.
影响因子：
6.5
作者：
S. Grundy;H. Mok;L. Zech;M. Berman
通讯作者：
S. Grundy;H. Mok;L. Zech;M. Berman
考来替泊、烟酸和洛伐他汀在治疗严重家族性高胆固醇血症中的互补作用。
影响因子：
39.2
作者：
Malloy,MJ;Kane,JP;Kunitake,ST;Tun,P
通讯作者：
Tun,P