Asthma and antibodies to pneumococcal virulence proteins.
Asthma and antibodies to pneumococcal virulence proteins.
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DOI：
10.1007/s15010-013-0482-3
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发表时间：
2013-10
期刊：
影响因子：
7.5
通讯作者：
Juhn YJ
中科院分区：
文献类型：
--
作者：
Zhao H;Jung JA;Briles DE;Kita H;Tsigrelis C;Juhn YJ
We previously reported that asthmatics had lower anti-serotype-specific pneumococcal polysaccharide antibody levels than non-asthmatics, and T-helper 2 (Th2)-immune profile was associated with suboptimal pneumococcal polysaccharide antibody. Our objective was to determine the influence of asthma status on anti-pneumococcal protein antigen antibody levels. We conducted a cross-sectional study, which enrolled 16 children and adults with asthma and 14 subjects without asthma. Asthma was ascertained by predetermined criteria. Serum IgG antibody levels to pneumococcal surface protein A (PspA), pneumococcal surface protein C (PspC), pneumococcal choline-binding protein A (PcpA), and pneumolysin (PLY) were measured by ELISA assays. These antibody levels were compared between asthmatics and non-asthmatics. Th2-immune profile was determined by IL-5 secretion from PBMCs cultured with house dust mite (HDM) and staphylococcal enterotoxin B (SEB) at day seven. The correlation between the anti-pneumococcal antibody levels and Th2-HDM and SEB-responsive immune profile was assessed. Of the 30 subjects, 16 (53%) were male and the median age was 26 years. There were no significant differences in anti-PspA, anti-PspC, anti-PcpA, and anti-PLY antibody levels between asthmatics and non-asthmatics. Th2-immune profile was inversely correlated with anti-PspC antibody levels (r= −0.53, p=0.003). This correlation was significantly modified by asthma status (r= −0.74, p=0.001 for asthmatics vs. r= −0.06, p=0.83 for non-asthmatics). Other pneumococcal protein antibodies were not correlated with Th2-immune profile. No significant differences in anti-pneumococcal protein antigen antibody levels between asthmatics and non-asthmatics were found. Asthma status is an important effect modifier determining the negative influence of Th2-immune profile on anti-PspC antibody levels.
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影响因子：
3.1
作者：
Glover, David T.;Hollingshead, Susan K.;Briles, David E.
通讯作者：
Briles, David E.
影响因子：
14.2
作者：
Juhn, Young J.;Kita, Hirohito;Jacobson, Robert M.
通讯作者：
Jacobson, Robert M.
影响因子：
14.2
作者：
Hanania, NA;Sockrider, M;Atmar, RL
通讯作者：
Atmar, RL
影响因子：
3.1
作者：
Briles, DE;Ades, E;Hollingshead, SK
通讯作者：
Hollingshead, SK
影响因子：
4.6
作者：
Baril, L.;Dietemann, J.;Cozon, G.
通讯作者：
Cozon, G.