Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy.
Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy.
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DOI：
10.1080/07357900802438585
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发表时间：
2009-05
影响因子：
2.4
通讯作者：
Achilefu S
中科院分区：
文献类型：
--
作者：
Odonkor CA;Achilefu S
尽管有令人信服的证据表明半胱天冬酶参与药物诱导的细胞凋亡，但肿瘤如何调节半胱天冬酶表达和活性以克服抗癌药物的细胞毒性尚不完全清楚。为了解决这个问题，我们研究了 caspase-3 和 7 在确定乳腺和肺肿瘤细胞系对化疗的反应中的作用。我们发现早期和晚期细胞凋亡反应分别与弱和强的细胞 caspase 激活相关。结果强调了时间性细胞凋亡反应与半胱天冬酶激活和耐药性之间的关系未被充分认识。此外，停药后肿瘤生长恢复的程度取决于 caspase-3 和 caspase-7 裂解的内源性阻断程度。这表明 caspase 调节在肿瘤复发中的作用尚未被认识，并表明靶向 caspase 裂解是增加癌症药物效力的合理方法。
In spite of compelling evidence implicating caspases in drug-induced apoptosis, how tumors modulate caspase expression and activity to overcome the cytotoxicity of anticancer agents is not fully understood. To address this issue, we investigated the role of caspases-3 and 7 in determining the response of breast and lung tumor cell lines to chemotherapy. We found that an early and late apoptotic response correlated with weak and strong cellular caspase-activation, respectively. The results highlight an underappreciated relationship of temporal apoptotic response with caspase-activation and drug-resistance. Moreover, the extent of tumor growth restoration after drug withdrawal was dependent on the degree of endogenous blockage of caspase-3 and caspase-7 cleavages. This points to an unrecognized role of caspase modulation in tumor recurrence and suggests that targeting caspase cleavage is a rational approach to increasing potency of cancer drugs.
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影响因子：
4.8
作者：
Park, SJ;Wu, CH;Safa, AR
通讯作者：
Safa, AR
影响因子：
3.5
作者：
Sanghavi, DM;Thelen, M;Rosen, A
通讯作者：
Rosen, A
影响因子：
8.8
作者：
LIEBMANN, JE;COOK, JA;LIPSCHULTZ, C;TEAGUE, D;FISHER, J;MITCHELL, JB
通讯作者：
MITCHELL, JB
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
DOI：
10.1073/pnas.191388598
发表时间：
2001-09-25
影响因子：
11.1
作者：
Gonçalves, A;Braguer, D;Jordan, MA
通讯作者：
Jordan, MA