Sacubitril Ameliorates Cardiac Fibrosis Through Inhibiting TRPM7 Channel.
Sacubitril Ameliorates Cardiac Fibrosis Through Inhibiting TRPM7 Channel.
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Sacubitril 通过抑制 TRPM7 通道改善心脏纤维化
DOI：
10.3389/fcell.2021.760035
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发表时间：
2021
影响因子：
5.5
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Jia T;Wang X;Tang Y;Yu W;Li C;Cui S;Zhu J;Meng W;Wang C;Wang Q
Heart failure caused by cardiac fibrosis has become a major challenge of public health worldwide. Cardiomyocyte programmed cell death (PCD) and activation of fibroblasts are crucial pathological features, both of which are associated with aberrant Ca2+ influx. Transient receptor potential cation channel subfamily M member 7 (TRPM7), the major Ca2+ permeable channel, plays a regulatory role in cardiac fibrosis. In this study, we sought to explore the mechanistic details for sacubitril, a component of sacubitril/valsartan, in treating cardiac fibrosis. We demonstrated that sacubitril/valsartan could effectively ameliorate cardiac dysfunction and reduce cardiac fibrosis induced by isoprotereno (ISO) in vivo. We further investigated the anti-fibrotic effect of sacubitril in fibroblasts. LBQ657, the metabolite of sacubitril, could significantly attenuate transforming growth factor-β 1 (TGF-β1) induced cardiac fibrosis by blocking TRPM7 channel, rather than suppressing its protein expression. In addition, LBQ657 reduced hypoxia-induced cardiomyocyte PCD via suppression of Ca2+ influx regulated by TRPM7. These findings suggested that sacubitril ameliorated cardiac fibrosis by acting on both fibroblasts and cardiomyocytes through inhibiting TRPM7 channel.
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影响因子：
6
作者：
Meyer BA;Doroudgar S
通讯作者：
Doroudgar S
影响因子：
4
作者：
Iborra-Egea O;Gálvez-Montón C;Roura S;Perea-Gil I;Prat-Vidal C;Soler-Botija C;Bayes-Genis A
通讯作者：
Bayes-Genis A
影响因子：
24
作者：
Cunningham, Jonathan W.;Claggett, Brian L.;Zile, Michael R.
通讯作者：
Zile, Michael R.
DOI：
10.1073/pnas.1311865110
发表时间：
2013-08-06
影响因子：
11.1
作者：
Sah, Rajan;Mesirca, Pietro;Clapham, David E.
通讯作者：
Clapham, David E.
影响因子：
8
作者：
Kong, Ping;Christia, Panagiota;Frangogiannis, Nikolaos G.
通讯作者：
Frangogiannis, Nikolaos G.