Cell competition from development to neurodegeneration.
Cell competition from development to neurodegeneration.
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DOI：
10.1242/dmm.048926
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发表时间：
2021-07-01
影响因子：
4.3
通讯作者：
Moreno E
中科院分区：
文献类型：
--
作者：
Costa-Rodrigues C;Couceiro J;Moreno E
细胞竞争是一个过程，通过这个过程，次优细胞被淘汰，以使具有更高适应度的细胞受益。它是一种监测机制，通过几种模式感知适应性状态的差异，如适应性指纹的表达，存活因子摄取率和对机械应力的抵抗力。适应性指纹介导的细胞竞争识别跨膜蛋白Flower的同种型，并通过Flower密码将细胞的相对适应性翻译成不同的命运。细胞竞争中的损伤增强了癌症和与衰老相关的病理等疾病的发展。在癌症中，恶性细胞获得超级竞争行为，杀死邻近细胞并超越组织，从而避免消除。神经退行性疾病影响数百万人，其特征在于认知能力下降和运动缺陷。阿尔茨海默病是痴呆症最常见的形式，也是研究最多的疾病之一。然而，发生的细胞过程仍然不清楚。黑腹果蝇是一种新兴的神经退行性疾病模型，由于其多功能性作为遗传研究的工具。对果蝇阿尔茨海默病模型的研究在次优和过度活跃的神经元中检测到了适应性标记，从而建立了细胞竞争和阿尔茨海默病之间的联系。在这篇综述中，我们概述了细胞竞争和与神经退行性疾病相关的新见解，并讨论了该领域的研究如何有助于开发这些疾病的新治疗靶点。总结：本文综述了细胞竞争作为一种主动选择机制，从其更成熟的分子途径到最近提出的神经退行性疾病的分子途径。
Cell competition is a process by which suboptimal cells are eliminated to the benefit of cells with higher fitness. It is a surveillance mechanism that senses differences in the fitness status by several modes, such as expression of fitness fingerprints, survival factor uptake rate and resistance to mechanical stress. Fitness fingerprints-mediated cell competition recognizes isoforms of the transmembrane protein Flower, and translates the relative fitness of cells into distinct fates through the Flower code. Impairments in cell competition potentiate the development of diseases like cancer and ageing-related pathologies. In cancer, malignant cells acquire a supercompetitor behaviour, killing the neighbouring cells and overtaking the tissue, thus avoiding elimination. Neurodegenerative disorders affect millions of people and are characterized by cognitive decline and locomotor deficits. Alzheimer's disease is the most common form of dementia, and one of the largely studied diseases. However, the cellular processes taking place remain unclear. Drosophila melanogaster is an emerging neurodegeneration model due to its versatility as a tool for genetic studies. Research in a Drosophila Alzheimer's disease model detected fitness markers in the suboptimal and hyperactive neurons, thus establishing a link between cell competition and Alzheimer's disease. In this Review, we overview cell competition and the new insights related to neurodegenerative disorders, and discuss how research in the field might contribute to the development of new therapeutic targets for these diseases. Summary: This Review presents cell competition as an active selection mechanism, from its more established molecular pathways to the recently proposed ones in neurodegenerative diseases.
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DOI：
10.3233/jpd-179001
发表时间：
2017
期刊：
Journal of Parkinson's disease
影响因子：
--
作者：
Braak H;Del Tredici K
通讯作者：
Del Tredici K
影响因子：
6.1
作者：
Braithwaite SP;Schmid RS;He DN;Sung ML;Cho S;Resnick L;Monaghan MM;Hirst WD;Essrich C;Reinhart PH;Lo DC
通讯作者：
Lo DC
影响因子：
4.3
作者：
Bedse G;Di Domenico F;Serviddio G;Cassano T
通讯作者：
Cassano T
DOI：
10.1073/pnas.1206171109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Busche, Marc Aurel;Chen, Xiaowei;Konnerth, Arthur
通讯作者：
Konnerth, Arthur
影响因子：
3.7
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
通讯作者：
Van Hoesen, Gary W.