Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection.

Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection.
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DOI:
10.1016/j.chom.2009.05.012
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发表时间:
2009-06-18
影响因子:
30.3
通讯作者:
Ploegh HL
Ploegh HL
中科院分区:
医学1区
文献类型:
--
作者:
Isaacson MK;Ploegh HL

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Ubiquitin is important for nearly every aspect of cellular physiology. All viruses rely extensively on host machinery for replication; therefore, it is not surprising that viruses connect to the ubiquitin pathway at many levels. Viral involvement with ubiquitin occurs either adventitiously because of the unavoidable usurpation of cellular processes, or for some specific purpose selected for by the virus to enhance viral replication. Here, we review current knowledge of how the ubiquitin pathway alters viral replication and how viruses influence the ubiquitin pathway to enhance their own replication.
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