Quality of life impact and recovery after ureteroscopy and stent insertion: insights from daily surveys in STENTS.

Quality of life impact and recovery after ureteroscopy and stent insertion: insights from daily surveys in STENTS.
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DOI:
10.1186/s12894-022-01004-9
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发表时间:
2022-04-06
期刊:
影响因子:
2
通讯作者:
NIDDK Urinary Stone Disease Research Network (USDRN)
NIDDK Urinary Stone Disease Research Network (USDRN)
中科院分区:
医学4区
文献类型:
--
作者:
Harper JD;Desai AC;Antonelli JA;Tasian GE;Ziemba JB;Al-Khalidi HR;Lai HH;Maalouf NM;Reese PP;Wessells HB;Kirkali Z;Scales CD Jr;NIDDK Urinary Stone Disease Research Network (USDRN)

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我们的目的是在研究中描述患者报告的支架相关症状(SAS)的日常演变和变化,以加强对支架相关症状(STENTS)的了解,这是一项前瞻性多中心观察性队列研究,使用了多个领域概念重叠的多种工具。在支架研究的嵌套队列中,最初的40名接受单侧输尿管镜检查(URS)和支架置入术的参与者接受了使用简明疼痛量表简表、患者报告结局测量信息系统测量疼痛严重程度和疼痛干扰、输尿管支架症状问卷泌尿评分、和下尿路功能障碍的症状研究网络症状指数。在术前、支架取出前每天和术后第30天(POD)记录疼痛强度、疼痛干扰、泌尿系统症状和困扰。中位年龄为44岁(IQR 29.58),53%为女性。主要结石的大小为7.5 mm(IQR 5,11),50%位于肾脏。评估类似概念的文书之间具有一致性。疼痛强度和泌尿系统症状从基线到POD 1增加,在前2天达到明显峰值,支架原位保持升高,个体间差异很大。疼痛引起的干扰和泌尿系统症状引起的困扰同样表现出较高的个体差异性。这是第一项调查日常SAS的研究,可以更深入地了解URS后的生活体验及其对生活质量的影响。测量疼痛强度、疼痛干扰和泌尿系统症状的不同仪器对患者的经历进行了一致的评估。URS后疼痛和泌尿系统症状的总体每日稳定性也以高患者水平的变化为标志,这表明有机会识别URS后重度SAS相关的特征。在线版本包含补充材料,可通过10.1186/s12894-022-01004-9获得。
Our objective was to describe day-to-day evolution and variations in patient-reported stent-associated symptoms (SAS) in the STudy to Enhance uNderstanding of sTent-associated Symptoms (STENTS), a prospective multicenter observational cohort study, using multiple instruments with conceptual overlap in various domains. In a nested cohort of the STENTS study, the initial 40 participants having unilateral ureteroscopy (URS) and stent placement underwent daily assessment of self-reported measures using the Brief Pain Inventory short form, Patient-Reported Outcome Measurement Information System measures for pain severity and pain interference, the Urinary Score of the Ureteral Stent Symptom Questionnaire, and Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index. Pain intensity, pain interference, urinary symptoms, and bother were obtained preoperatively, daily until stent removal, and at postoperative day (POD) 30. The median age was 44 years (IQR 29,58), and 53% were female. The size of the dominant stone was 7.5 mm (IQR 5,11), and 50% were located in the kidney. There was consistency among instruments assessing similar concepts. Pain intensity and urinary symptoms increased from baseline to POD 1 with apparent peaks in the first 2 days, remained elevated with stent in situ, and varied widely among individuals. Interference due to pain, and bother due to urinary symptoms, likewise demonstrated high individual variability. This first study investigating daily SAS allows for a more in-depth look at the lived experience after URS and the impact on quality of life. Different instruments measuring pain intensity, pain interference, and urinary symptoms produced consistent assessments of patients’ experiences. The overall daily stability of pain and urinary symptoms after URS was also marked by high patient-level variation, suggesting an opportunity to identify characteristics associated with severe SAS after URS. The online version contains supplementary material available at 10.1186/s12894-022-01004-9.
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