Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study.
Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study.
复制标题
梗塞位置和大小对左心房功能的影响：心血管磁共振特征跟踪研究
DOI：
10.3390/jcm11236938
复制
发表时间：
2022-11-24
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
背景：LA功能已被认为是许多心血管疾病的重要预后指标。心血管磁共振特征跟踪（CMR-FT）是一种很有前途的左心房功能评价技术。心肌梗死的大小和部位是引起左室重构不良的重要因素，但对左心房的影响尚不清楚。目的：应用CMR-FT技术探讨心肌梗死部位和大小对LA功能的影响。研究类型：回顾性。人群：以前诊断为前路心肌梗死（n = 42）或非前路心肌梗死（n = 40）的患者和健康对照（n = 47）。场强/序列：3.0T MR，稳态自由进动（SSFP），相敏反转恢复（PSIR）。评估：通过晚期钆增强（LGE）成像确定梗死位置和大小。利用CMR-FT分析了2室和4室电影图像的LA性能，包括LA水库，导管和增压泵功能。统计学：描述性统计、Bonferroni后校正方差分析、Kruskal-Wallis H、Spearman相关、类内相关系数。结果：前路心肌梗死患者左心室储层功能（LATEF, εs, SRs）、导管功能（LAPEF, εe, SRs）、增压泵功能（LAAEF, εa）与对照组比较差异有统计学意义（p < 0.05）。非前路心肌梗死患者LA strain受损（εs, εe, εa; p < 0.05）， LAEFs保留（p < 0.05）。调整心肌梗死面积后，前壁组和非前壁组的LA形态和功能无显著差异。心肌梗死大小的分层分析显示，心肌梗死大小≤15%的患者与对照组相比，LA体积和LAEFs没有变化（p < 0.05）；只有εs和εe降低(p < 0.05)。心肌梗死大小≤15%组与心肌梗死大小≤15%组相比，LAVIpre-a、LAVImin升高，LATEF和LAAEF降低（p < 0.05）。多元逐步回归分析显示，LVSVI、εs和MI大小与LAVI pre-a呈显著相关。资料结论：心肌梗死部位不是影响左心房形态和功能的主要因素。心肌梗死大小≤15%的患者比心肌梗死大小≤15%的患者有更明显的梗死后LA重构和功能障碍。
Background: LA function has been recognized as a significant prognostic marker in many cardiovascular diseases. Cardiovascular magnetic resonance feature tracking (CMR-FT) represents a promising technique for left atrial function evaluation. The size and location of myocardial infarction are important factors in the cause of adverse left ventricular remodeling, but the effect on the left atriam is unclear. Purpose: to investigate the effect of location and size of previous myocardial infarction (MI) on LA function using CMR-FT. Study type: retrospective. Population: patients formerly diagnosed with anterior MI (n = 42) or non-anterior MI (n = 40) and healthy controls (n = 47). Field Strength/Sequence: a 3.0T MR, Steady state free precession (SSFP), Phase-sensitive inversion recovery (PSIR). Assessment: infarct location and size were assigned and quantified by late-gadolinium enhancement (LGE) imaging. LA performance was analyzed using CMR-FT in 2- and 4-chamber cine images, including LA reservoir, conduit and booster pump function. Statistics: descriptive statistics, ANOVA with post Bonferroni correction, Kruskal–Wallis H, Spearman’s correlation, intraclass correlation coefficient. Results: Anterior MI patients had impaired LA reservoir function (LATEF, εs, SRs), conduit function (LAPEF, εe, SRs) and booster pump function (LAAEF, εa) compared with controls (p < 0.05). Non-anterior MI patients had impaired LA strain (εs, εe, εa; p < 0.05) but preserved LAEFs (p > 0.05). After adjusting the area of MI, there was no significant difference in the LA morphology and function between the anterior and non-anterior wall groups. Stratification analysis by MI size revealed that LA volumes and LAEFs were unchanged in patients with MI size ≤ 15% compared with controls (p > 0.05); only εs and εe were decreased (p < 0.05). Increased LAVIpre-a, LAVImin and decreased LATEF, and LAAEF were found in patients with MI size > 15% compared with the MI size ≤ 15% group (p < 0.05). LVSVI, εs and MI size were significant correlated with LAVI pre-a in multiple stepwise regression analysis. Data conclusions: The location of myocardial infarction is not a major factor affecting the morphology and function of the left atrium. Patients with MI size > 15% experience more pronounced post-infarction LA remodeling and dysfunction than MI size ≤ 15% patients.
登录
查看更多内容
通过 CMR 特征跟踪评估高血压患者左心房功能障碍的早期检测
影响因子：
5.9
作者：
Li, Lu;Chen, Xiuyu;Zhao, Shihua
通讯作者：
Zhao, Shihua
影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
2.4
作者：
Nayyar, Dhruv;Nguyen, Tuan;Otton, James
通讯作者：
Otton, James
影响因子：
6.2
作者：
Morris, Daniel A.;Takeuchi, Masaaki;Boldt, Leif-Hendrik
通讯作者：
Boldt, Leif-Hendrik
影响因子：
14
作者：
Ortiz-Perez, Jose T.;Rodriguez, Jose;Wu, Edwin
通讯作者：
Wu, Edwin