Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis.
Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis.
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DOI：
10.3390/cells10112815
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发表时间：
2021-10-20
期刊：
影响因子：
6
通讯作者：
King MR
中科院分区：
文献类型：
--
作者：
Dombroski JA;Hope JM;Sarna NS;King MR
癌症转移是世界范围内死亡的主要原因之一，促使研究确定预防癌症转移的新方法。最近，人们越来越感兴趣地了解癌细胞如何将机械力转化为生化信号，因为转移是一个由广泛的物理力组成的过程。例如，扩散的癌细胞必须通过的循环系统是以由于血流而引起的可变流体剪切应力为特征的环境。癌细胞和其他细胞可以使用机械敏感离子通道Piezo1将物理刺激转化为生化反应，Piezo1通过细胞暴露于物理力时发生的膜变形激活。当激活时，Piezo1打开，允许钙流入细胞。钙离子作为一种普遍存在的第二信使阳离子，与许多参与肿瘤转移的信号通路相关，如血管生成、细胞迁移、血管内渗和增殖。在这篇综述中，我们讨论了Piezo1在癌症转移的各个阶段中的作用，以及它在免疫细胞活化和癌细胞死亡中的作用。
Cancer metastasis is one of the leading causes of death worldwide, motivating research into identifying new methods of preventing cancer metastasis. Recently there has been increasing interest in understanding how cancer cells transduce mechanical forces into biochemical signals, as metastasis is a process that consists of a wide range of physical forces. For instance, the circulatory system through which disseminating cancer cells must transit is an environment characterized by variable fluid shear stress due to blood flow. Cancer cells and other cells can transduce physical stimuli into biochemical responses using the mechanosensitive ion channel Piezo1, which is activated by membrane deformations that occur when cells are exposed to physical forces. When active, Piezo1 opens, allowing for calcium flux into the cell. Calcium, as a ubiquitous second-messenger cation, is associated with many signaling pathways involved in cancer metastasis, such as angiogenesis, cell migration, intravasation, and proliferation. In this review, we discuss the roles of Piezo1 in each stage of cancer metastasis in addition to its roles in immune cell activation and cancer cell death.
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影响因子：
8
作者：
Buache, E.;Etique, N.;Alpy, F.;Stoll, I.;Muckensturm, M.;Reina-San-Martin, B.;Chenard, M. P.;Tomasetto, C.;Rio, M. C.
通讯作者：
Rio, M. C.
影响因子：
4.6
作者：
Chen J;Zhou W;Jia Q;Chen J;Zhang S;Yao W;Wei F;Zhang Y;Yang F;Huang W;Zhang Y;Zhang H;Zhang Y;Huang B;Zhang Z;Jia H;Wang N
通讯作者：
Wang N
影响因子：
4.3
作者：
Blomberg OS;Spagnuolo L;de Visser KE
通讯作者：
de Visser KE
影响因子：
6
作者：
Emig R;Knodt W;Krussig MJ;Zgierski-Johnston CM;Gorka O;Groß O;Kohl P;Ravens U;Peyronnet R
通讯作者：
Peyronnet R
影响因子：
5.9
作者：
Ellefsen, Kyle L.;Holt, Jesse R.;Pathak, Medha M.
通讯作者：
Pathak, Medha M.