Immune regulation of metastasis: mechanistic insights and therapeutic opportunities.
Immune regulation of metastasis: mechanistic insights and therapeutic opportunities.
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DOI：
10.1242/dmm.036236
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发表时间：
2018-10-24
影响因子：
4.3
通讯作者：
de Visser KE
中科院分区：
文献类型：
--
作者：
Blomberg OS;Spagnuolo L;de Visser KE
转移性疾病是癌症患者死亡的主要原因。转移形成涉及一系列事件，其潜在机制仍然知之甚少。在转移级联过程中，癌细胞与免疫系统紧密相互作用，它们在肿瘤微环境和全身都相互影响。癌症和免疫细胞之间的串扰为我们对转移形成的理解增加了另一层复杂性，但同时为癌症患者开辟了新的治疗机会。随着免疫治疗策略的不断发展，需要更好地了解转移的免疫调节，以最大限度地提高转移性疾病患者的治疗效果。在这篇综述和随附的海报中，我们描述了迄今为止报道的转移免疫调节的主要机制，并提出了目前可用的或在不久的将来可能成为解决转移的有希望的免疫选择。总结：在这篇综述和随附的海报中，我们讨论了免疫系统在转移中的双重作用，并总结了靶向肿瘤免疫相互作用的有前景的治疗策略。
Metastatic disease is the leading cause of death in cancer patients. Metastasis formation involves a cascade of events for which the underlying mechanisms are still poorly understood. During the metastatic cascade, cancer cells tightly interact with the immune system and they influence each other, both in the tumor microenvironment and systemically. The crosstalk between cancer and immune cells adds another layer of complexity to our understanding of metastasis formation, but at the same time opens new therapeutic opportunities for cancer patients. The intensifying development of immunotherapeutic strategies calls for a better understanding of immune regulation of metastasis in order to maximize the therapeutic benefit for patients with metastatic disease. In this Review and accompanying poster, we describe the main mechanisms of immune regulation of metastasis that have been reported to date, and present promising immunotherapeutic options that are currently available, or may become so in the near future, to tackle metastasis. Summary: In this Review and accompanying poster, we discuss the dual role of the immune system in metastasis and summarize promising therapeutic strategies to target tumor-immune interactions.
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影响因子：
11.2
作者：
Acuff, HB;Carter, KJ;Matrisian, LM
通讯作者：
Matrisian, LM
影响因子：
20.3
作者：
Camerer, E;Qazi, AA;Coughlin, SR
通讯作者：
Coughlin, SR
影响因子：
--
作者：
Choudhry H;Helmi N;Abdulaal WH;Zeyadi M;Zamzami MA;Wu W;Mahmoud MM;Warsi MK;Rasool M;Jamal MS
通讯作者：
Jamal MS
影响因子：
5.4
作者：
Contini, P;Ghio, M;Puppo, F
通讯作者：
Puppo, F
影响因子：
8.8
作者：
Byrne KT;Vonderheide RH
通讯作者：
Vonderheide RH