Transcriptional architecture of the mammalian circadian clock.
Transcriptional architecture of the mammalian circadian clock.
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DOI：
10.1038/nrg.2016.150
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Takahashi JS
中科院分区：
文献类型：
--
作者：
Takahashi JS
生物钟是一种内源振荡器，控制着生物体的24小时生理和行为过程。这些细胞自主时钟由一个基于转录翻译的自动调节反馈环组成。随着下一代测序方法的发展，生物化学和基因组学对昼夜节律功能的洞察最近成为关注的焦点。对时钟转录反馈环的全基因组分析揭示了转录因子占据、RNA聚合酶II招募和启动、新生转录和染色质重塑的全球昼夜节律。生物钟的基因组靶标无处不在，与新陈代谢、细胞生长和生理调节密切相关。
Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioral processes in organisms. These cell-autonomous clocks are composed of a transcription–translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription and chromatin remodelling. The genomic targets of the circadian clock are pervasive and are intimately linked to the regulation of metabolism, cell growth and physiology.
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DOI：
10.1073/pnas.1612917113
发表时间：
2016-10-11
影响因子：
11.1
作者：
Chiou, Yi-Ying;Yang, Yanyan;Sancar, Aziz
通讯作者：
Sancar, Aziz
影响因子：
4.8
作者：
Annayev, Yunus;Adar, Sheera;Ye, Rui
通讯作者：
Ye, Rui
影响因子：
16.8
作者：
Ameur, Adam;Zaghlool, Ammar;Feuk, Lars
通讯作者：
Feuk, Lars
影响因子：
30.8
作者：
Bonnefond, Amelie;Clement, Nathalie;Fawcett, Katherine;Yengo, Loic;Vaillant, Emmanuel;Guillaume, Jean-Luc;Dechaume, Aurelie;Payne, Felicity;Roussel, Ronan;Czernichow, Sebastien;Hercberg, Serge;Hadjadj, Samy;Balkau, Beverley;Marre, Michel;Lantieri, Olivier;Langenberg, Claudia;Bouatia-Naji, Nabila;Charpentier, Guillaume;Vaxillaire, Martine;Rocheleau, Ghislain;Wareham, Nicholas J.;Sladek, Robert;McCarthy, Mark I.;Dina, Christian;Barroso, Ines;Jockers, Ralf;Froguel, Philippe
通讯作者：
Froguel, Philippe
影响因子：
18.2
作者：
Allada R;Chung BY
通讯作者：
Chung BY