Circadian organization of behavior and physiology in Drosophila.

Circadian organization of behavior and physiology in Drosophila.
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DOI:
10.1146/annurev-physiol-021909-135815
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发表时间:
2010
影响因子:
18.2
通讯作者:
Chung BY
Chung BY
中科院分区:
医学1区
文献类型:
--
作者:
Allada R;Chung BY

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生物钟组织行为和生理以适应日常环境周期。遗传学方法在果蝇,果蝇,揭示了广泛保守的分子齿轮这些24小时定时器。然而,关于这些细胞自主时钟如何传递时间信息以调节细胞功能,人们知之甚少。在这里,我们讨论了我们目前的知识在果蝇的生物钟功能,提供了一个概述的生物钟的分子基础。然后,我们描述了神经网络的重要昼夜节律的运动活动,包括如何这些分子时钟可能会影响神经元功能。最后,我们解决了一系列的行为和生理系统调节的生物钟,包括特定的外围振荡器和关键分子效应器,他们已经描述的讨论。这些研究揭示了一个显着的复杂性,昼夜节律的途径,在这个“简单”的模式生物。
Circadian clocks organize behavior and physiology to adapt to daily environmental cycles. Genetic approaches in the fruit fly, Drosophila melanogaster, have revealed widely conserved molecular gears of these 24-h timers. Yet much less is known about how these cell-autonomous clocks confer temporal information to modulate cellular functions. Here we discuss our current knowledge of circadian clock function in Drosophila, providing an overview of the molecular underpinnings of circadian clocks. We then describe the neural network important for circadian rhythms of locomotor activity, including how these molecular clocks might influence neuronal function. Finally, we address a range of behaviors and physiological systems regulated by circadian clocks, including discussion of specific peripheral oscillators and key molecular effectors where they have been described. These studies reveal a remarkable complexity to circadian pathways in this “simple” model organism.
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