Distinct neural representations of placebo and nocebo effects.
Distinct neural representations of placebo and nocebo effects.
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DOI：
10.1016/j.neuroimage.2015.03.015
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发表时间：
2015-05-15
期刊：
影响因子：
5.7
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Freeman S;Yu R;Egorova N;Chen X;Kirsch I;Claggett B;Kaptchuk TJ;Gollub RL;Kong J
期望塑造了我们体验世界的方式。在这项研究中，我们使用功能磁共振成像来研究积极和消极期望如何改变同一队列受试者的疼痛体验。我们首先操纵受试者对三种惰性药膏治疗效果的预期，其中一种药膏标记为“利多卡因”（积极预期），一种标记为“辣椒素”（消极预期），另一种标记为“中性”，分别暗中降低、增加或不改变药膏施用后的有害刺激强度。然后，我们使用功能磁共振成像（fMRI）来研究在治疗和对照霜前后给予相同疼痛刺激的信号变化。24名健康成年人完成了这项研究。结果显示预期显著调节主观疼痛评分。在控制了中性条件的变化后，积极期望和消极期望诱发的主观疼痛评分变化显著相关。fMRI结果显示，疼痛增加的预期引起脑岛、眶额叶皮层和导水管周围灰质的显著fMRI信号变化，而疼痛缓解的预期引起纹状体显著的fMRI信号变化。没有大脑区域被确定为“辣椒素”和“利多卡因”条件反射的共同区域。大脑对由积极期望和消极期望引起的疼痛矩阵中相同的有害刺激的反应之间也没有显著的关联。我们的研究结果表明，积极和消极的期望参与不同的大脑网络来调节我们的疼痛体验，但总的来说，这些不同的神经激活模式导致了相关的安慰剂和反安慰剂行为反应。
Expectations shape the way we experience the world. In this study, we used fMRI to investigate how positive and negative expectation can changes pain experiences in the same cohort of subjects. We first manipulated subjects’ treatment expectation of the effectiveness of three inert creams, with one cream labeled “Lidocaine” (positive expectancy), one labeled “Capsaicin” (negative expectancy) and one labeled “Neutral” by surreptitiously decreasing, increasing, or not changing respectively, the intensity of the noxious stimuli administered following cream application. We then used fMRI to investigate the signal changes associated with administration of identical pain stimuli before and after the treatment and control creams. Twenty-four healthy adults completed the study. Results showed expectancy significantly modulated subjective pain ratings. After controlling for changes in the neutral condition, the subjective pain rating changes evoked by positive and negative expectancy were significantly associated. fMRI results showed that the expectation of an increase in pain induced significant fMRI signal changes in the insula, orbitofrontal cortex, and periaqueductal gray, whereas the expectation of pain relief evoked significant fMRI signal changes in the striatum. No brain regions were identified as common to both “Capsaicin” and “Lidocaine” conditioning. There was also no significant association between the brain response to identical noxious stimuli in the pain matrix evoked by positive and negative expectancy. Our findings suggest that positive and negative expectancy engage different brain networks to modulate our pain experiences, but, overall, these distinct patterns of neural activation result in a correlated placebo and nocebo behavioral response.
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DOI：
10.1001/jama.2012.115
发表时间：
2012-02-08
期刊：
JAMA
影响因子：
--
作者：
Colloca L;Finniss D
通讯作者：
Finniss D
影响因子：
2.5
作者：
Colloca, Luana;Benedetti, Fabrizio
通讯作者：
Benedetti, Fabrizio
影响因子：
16.2
作者：
Eippert, Falk;Bingel, Ulrike;Buechel, Christian
通讯作者：
Buechel, Christian
影响因子：
10.6
作者：
Baur, Volker;Haenggi, Juergen;Jaencke, Lutz
通讯作者：
Jaencke, Lutz
影响因子：
5.7
作者：
Brodersen, Kay H.;Wiech, Katja;Lomakina, Ekaterina I.;Lin, Chia-shu;Buhmann, Joachim M.;Bingel, Ulrike;Ploner, Markus;Stephan, Klaas Enno;Tracey, Irene
通讯作者：
Tracey, Irene