The objective assessment of lifetime cumulative ultraviolet exposure for determining melanoma risk.
The objective assessment of lifetime cumulative ultraviolet exposure for determining melanoma risk.
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客观评估终生累积紫外线暴露以确定黑色素瘤风险。
DOI：
10.1016/j.jphotobiol.2006.08.002
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Cockburn,Myles
中科院分区：
文献类型：
--
作者：
Tatalovich,Zaria;Wilson,JohnP;Mack,Thomas;Yan,Ying;Cockburn,Myles
暴露于紫外线辐射通常被认为是黑色素瘤最重要的环境风险因素。然而，测量人类的紫外线暴露已被证明具有挑战性。尽管人们普遍认为，需要一个客观的指标，为个人紫外线照射，以适当地评估黑色素瘤的风险，很少有人注意到的问题，紫外线照射测量的准确性。本研究利用了基于GIS的历史紫外线暴露模型（暴露估计的准确性是已知的），并在病例对照设置中研究了与自我报告的户外活动时间相比，紫外线暴露在黑色素瘤风险中的相对重要性。紫外线估计值与来自洛杉矶县65岁以下的非西班牙裔白色居民中的820例代表性黑素瘤病例的居住史以及与病例按年龄、性别、种族和居住区相匹配的877例对照相结合，以计算累积终生紫外线暴露和平均年紫外线暴露。对于历史测量，当参与者居住在美国境外时，我们还计算了紫外线估计值。虽然没有增加与自我报告的户外活动时间相关的黑色素瘤风险，但基于居住史的年平均紫外线暴露与黑色素瘤风险之间的关联是实质性的，基于居住史的累积紫外线暴露与黑色素瘤之间的关联也是如此。在任何年龄层中，户外活动的时间似乎对黑色素瘤风险没有显著影响，然而，当根据居住史调整紫外线暴露时，年轻时户外活动的时间显着增加了黑色素瘤的风险。虽然当我们排除海外居民的数据时，风险有所减弱（正如我们所知道的所有其他研究所做的那样），但这并没有显著影响随后的紫外线暴露对黑色素瘤的风险估计。
Exposure to ultraviolet radiation has commonly been recognized as the most important environmental risk factor for melanoma. The measurement of UV exposure in humans, however, has proved challenging. Despite the general appreciation that an objective metric for individual UV exposure is needed to properly assess melanoma risk, little attention has been given to the issue of accuracy of UV exposure measurement. The present research utilized a GIS based historical UV exposure model (for which the accuracy of exposure estimates is known) and examined, in the case–control setting, the relative importance of UV exposure compared to self-reported time spent outdoors, in melanoma risk. UV estimates were coupled with residential histories of 820 representative melanoma cases among non-Hispanic white residents under 65 years of age from Los Angeles County and for 877 controls matched to cases by age, sex, race, and neighborhood of residence, to calculate the cumulative lifetime UV exposure and average annual UV exposure. For historical measures, when the participants resided outside the US, we also calculated UV estimates. While there was no increased risk of melanoma associated with self-reported time spent outdoors, the association between annual average UV exposure based on residential history and melanoma risk was substantial, as was the association between cumulative UV exposure based on residential history and melanoma. The time spent in outdoor activities appeared to have no significant effect on melanoma risk in any age strata, however, when adjusted for UV exposure based on residential history, time spent outdoors during young age significantly increased risk for melanoma. While there was some attenuation of risk when we excluded data from people resident overseas (as all other studies we are aware of have done), this did not significantly impact subsequent risk estimates of UV exposure on melanoma.
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皮肤恶性黑色素瘤和总累积阳光照射指标：分离组织遗传学类型的分析。
DOI：
10.1093/jnci/73.1.75
发表时间：
1984
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
C. Holman;Bruce K. Armstrong
通讯作者：
Bruce K. Armstrong
臭氧消耗对健康和环境的影响。
DOI：
--
发表时间：
1989
期刊：
影响因子：
--
作者：
RobinRussell Jones;T. Wigley
通讯作者：
T. Wigley
DOI：
--
发表时间：
1990
期刊：
影响因子：
--
作者：
J. Lodge
通讯作者：
J. Lodge
光生物学中的辐射测量
DOI：
--
发表时间：
1989
期刊：
影响因子：
--
作者：
B. Diffey
通讯作者：
B. Diffey
同时比较两个人群在不同海拔高度的个人紫外线暴露量。
影响因子：
2.2
作者：
M. Kimlin;J. Wong;A. Parisi
通讯作者：
A. Parisi