Role of IL12 in the development of human Th1 type cells.
Role of IL12 in the development of human Th1 type cells.
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IL12 在人类 Th1 型细胞发育中的作用。
DOI：
10.1016/0923-2494(96)83015-x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
E. Maggi
中科院分区：
文献类型：
--
作者：
S. Romagnani;R. Manetti;F. Annunziato;E. Maggi
生物体对感染性病原体的反应涉及免疫细胞和炎性细胞之间的复杂相互作用，其由细胞因子网络调节。细胞因子在宿主对病原体的防御机制中，无论是在抗原特异性、适应性免疫还是在先天或天然抗性中，在效应细胞和辅助调节细胞之间的相互作用中发挥重要作用。天然免疫机制具有低水平的特异性，可在感染后数分钟或数小时内激活，并提供第一道非特异性防线。然而，大多数情况下，只有在几天内诱导适应性（特异性）免疫应答，才能清除感染因子，例如细菌或病毒。在某些情况下（特别是在细胞外寄生虫感染后），特异性效应子应答主要基于可溶性抗体的产生（体液免疫）。通过观察到鼠和人的CD4+辅助性T（Th）细胞都包含基于其细胞因子分泌谱的功能异质性群体，已经使这种二分法的机制变得更加清楚（Mosmann和Coffman，1989; Romagnani，1991）。Thl细胞产生IFN γ和TNFP，而Th2细胞产生IL4和IL5。其他细胞因子，如IL2、IL3、GM-CSF、TNF α、IL6、IL10和IL13，特别是在人中，由两种Th细胞亚群共同产生。在发现活化巨噬细胞的产物IL 12是T淋巴细胞和NK细胞产生IFN γ的强诱导剂之后（小林等人，1989），我们假设响应于细胞内寄生虫的巨噬细胞感染而释放的IL 12可以在Th细胞分化为Th 1样亚群中起关键作用
The response of the organism to infectious pathogens involves a complex interaction between immune and inflammatory cells which are regulated by a network of cytokines. Cytokines play an important role in the interaction between effector cells and accessory regulatory cells during host defence mechanisms in response to pathogens, both in antigen-specific, adaptive immunity and in innate or natural resistance. The mechanisms of natural immunity, which possesses a low level of specificity, can be activated within minutes or hours after infection and provide a first, non-specific, line of defence. Most of the time, however, it is only with the induction of the adaptive (specific) immune response within a few days that clearance of the infectious agents, eg bacteria or viruses, is accomplished. In some circumstances (particularly following infections by extracellular parasites), the specific effector response is mainly based on the production of soluble antibodies (humoral immunity). In contrast, cell-mediated immune reactions predominate in response to intracellular parasites.The mechanisms responsible for this dichotomy have been made clearer by the observation that both murine and human CD4+ T helper (Th) cells comprise functionally heterogenous populations based on their profile of cytokine secretion (Mosmann and Coffman, 1989; Romagnani, 1991). Thl cells produce IFNy and TNFP, whereas Th2 cells produce IL4 and IL5. Other cytokines, such as IL2, IL3, GM-CSF, TNFa, IL6, IL10 and IL13, particularly in humans, are variably produced by both Th cell subsets. After the discovery that IL12, a product of activated macrophages, was a powerful inducer of IFNy production by both T lymphocytes and NK cells (Kobayashi et al., 1989), we hypothesized that IL12 released in response to macrophage infection by intracellular parasites could play a key role in the differentiation of Th cells into the Thl-like subset
树突状细胞和产生 IFN-α 的细胞是人外周血中两种功能不同的非 B、非单核 HLA-DR 细胞亚群。
影响因子：
6.4
作者：
Chehimi,J;Starr,SE;Kawashima,H;Miller,DS;Trinchieri,G;Perussia,B;Bandyopadhyay,S
通讯作者：
Bandyopadhyay,S
影响因子：
56.9
作者：
HSIEH, CS;MACATONIA, SE;MURPHY, KM
通讯作者：
MURPHY, KM