Involvement of endocytosis and alternative splicing in the formation of the pathological process in the early stages of Parkinson's disease.
Involvement of endocytosis and alternative splicing in the formation of the pathological process in the early stages of Parkinson's disease.
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DOI：
10.1155/2014/718732
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发表时间：
2014
影响因子：
--
通讯作者：
Slominsky PA
中科院分区：
文献类型：
--
作者：
Alieva AKh;Shadrina MI;Filatova EV;Karabanov AV;Illarioshkin SN;Limborska SA;Slominsky PA
Parkinson's disease (PD) is the one of most widespread neurodegenerative pathologies. Because of the impossibility of studying the endogenous processes that occur in the brain of patients with PD in the presymptomatic stage, the mechanisms that trigger the disease remain unknown. Thus, the identification of the processes that play an important role in the early stages of the disease in these patients is extremely difficult. In this context, we performed a whole-transcriptome analysis of the peripheral blood of untreated patients with stage 1 PD (Hoehn-Yahr scale). We demonstrated a significant change in the levels of transcripts included in the large groups of processes associated with the functioning of the immune system and cellular transport. Moreover, a significant change in the splicing of genes involved in cellular-transport processes was shown in our study.
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影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
人类大脑发育和衰老过程中广泛的剪接变化
影响因子：
9.9
作者：
Mazin, Pavel;Xiong, Jieyi;Khaitovich, Philipp
通讯作者：
Khaitovich, Philipp
影响因子：
14.9
作者：
Barrett T;Troup DB;Wilhite SE;Ledoux P;Evangelista C;Kim IF;Tomashevsky M;Marshall KA;Phillippy KH;Sherman PM;Muertter RN;Holko M;Ayanbule O;Yefanov A;Soboleva A
通讯作者：
Soboleva A
影响因子：
2.2
作者：
Keyser, Rowena J.;Lombard, Debbie;Bardien, Soraya
通讯作者：
Bardien, Soraya
影响因子：
8.6
作者：
Goetz, CG;Poewe, W;Seidl, L
通讯作者：
Seidl, L