Insect muscle actins differ distinctly from invertebrate and vertebrate cytoplasmic actins
Insect muscle actins differ distinctly from invertebrate and vertebrate cytoplasmic actins
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昆虫肌肉肌动蛋白与无脊椎动物和脊椎动物细胞质肌动蛋白明显不同
DOI：
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发表时间：
1992
影响因子：
3.9
通讯作者：
J. Prudhomme
中科院分区：
文献类型：
--
作者：
N. Mounier;M. Gouy;D. Mouchiroud;J. Prudhomme
无脊椎动物的肌动蛋白类似于脊椎动物的细胞质肌动蛋白，而肌肉肌动蛋白和细胞质肌动蛋白之间的区别并不像脊椎动物的肌动蛋白那样明确。然而，家蚕和果蝇有肌动蛋白基因在肌肉中特异性表达。为了探讨肌动蛋白与细胞质肌动蛋白的基因表达差异是否与相应基因的序列有关，我们比较了这两种昆虫和其他后生动物的肌动蛋白基因序列。我们发现昆虫肌动蛋白形成了一个由大约10种肌肉特异性氨基酸组成的相关蛋白家族。昆虫肌动蛋白已明显地从细胞质动蛋白中分化出来，并从一组密切相关的蛋白质中形成一个单系群，包括昆虫和脊椎动物的细胞质动蛋白以及软体动物、蜗牛和线虫的肌动蛋白。我们提出，肌肉特异性肌动蛋白基因在动物进化过程中至少独立出现过两次：昆虫肌肉肌动蛋白基因是从节肢动物门的细胞质肌动蛋白基因中出现的，而脊椎动物肌肉肌动蛋白基因则是在脊索动物谱系中进化而来的。
SummaryInvertebrate actins resemble vertebrate cytoplasmic actins, and the distinction between muscle and cytoplasmic actins in invertebrates is not well established as for vertebrate actins. However, Bombyx and Drosophila have actin genes specifically expressed in muscles. To investigate if the distinction between muscle and cytoplasmic actins evidenced by gene expression analysis is related to the sequence of corresponding genes, we compare the sequences of actin genes of these two insect species and of other Metazoa. We find that insect muscle actins form a family of related proteins characterized by about 10 muscle-specific amino acids. Insect muscle actins have clearly diverged from cytoplasmic actins and form a monophyletic group emerging from a cluster of closely related proteins including insect and vertebrate cytoplasmic actins and actins of mollusc, cestode, and nematode. We propose that muscle-specific actin genes have appeared independently at least twice during the evolution of animals: insect muscle actin genes have emerged from an ancestral cytoplasmic actin gene within the arthropod phylum, whereas vertebrate muscle actin genes evolved within the chordate lineage as previously described.
影响因子：
5.6
作者：
KRAUSE, M;WILD, M;HIRSH, D
通讯作者：
HIRSH, D