The Relationship Between Type 2 Diabetes, NAFLD, and Cardiovascular Risk.
The Relationship Between Type 2 Diabetes, NAFLD, and Cardiovascular Risk.
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DOI：
10.1007/s11892-021-01383-7
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发表时间：
2021-03-19
影响因子：
4.2
通讯作者：
Loomba R
中科院分区：
文献类型：
--
作者：
Caussy C;Aubin A;Loomba R
非酒精性脂肪性肝病（NAFLD）和2型糖尿病（T2DM）密切相关。两者都与心血管疾病（CVD）的风险增加有关。一些研究提供了证据表明，NAFLD可能是一个独立的CVD危险因素。鉴于NAFLD和T2DM之间的强相关性，评估这两种疾病的独立CV效应仍然具有挑战性。然而，与不伴有NAFLD的T2 DM患者相比，患有T2 DM和NAFLD的患者表现出更高的CVD风险，这表明患有T2 DM和NAFLD的患者的CV风险可能协同增加，这得到了几种共同的病理生理途径的支持。几种抗糖尿病疗法已显示出对NAFLD和CVD的有益作用。T2DM和NAFLD患者应被视为CVD高风险患者，可从更强化的CV预防中获益。需要额外的长期随访来证明NAFLD的治疗有效地降低了CVD的风险。
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are strongly associated. Both also associate with an increased risk of cardiovascular disease (CVD). Several studies have provided evidence that NAFLD could be an independent CVD risk factor. Given the strong association between NAFLD and T2DM, assessing the independent CV effect of these two conditions remains challenging. However, patients with T2DM and NAFLD exhibit higher risk of CVD compared with T2DM without NAFLD suggesting a potential synergistic increase of CV risk in patients with both T2DM and NAFLD supported by several shared pathophysiological pathways. Several anti-diabetic therapies have shown beneficial effect on both NAFLD and CVD. Patients with T2DM and NAFLD should be considered at high risk of CVD and could benefit from more intensive CV prevention. Additional long-term follow-up is needed to demonstrate that the treatment of NAFLD effectively reduces the risk of CVD.
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影响因子：
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