Changes in the Intestinal Microbiome and Alcoholic and Nonalcoholic Liver Diseases: Causes or Effects?
Changes in the Intestinal Microbiome and Alcoholic and Nonalcoholic Liver Diseases: Causes or Effects?
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DOI：
10.1053/j.gastro.2016.02.073
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发表时间：
2016-06
期刊：
影响因子：
29.4
通讯作者：
Bajaj JS
中科院分区：
文献类型：
--
作者：
Betrapally NS;Gillevet PM;Bajaj JS
脂肪性肝病的患病率在全球范围内迅速上升；在丙型肝炎病毒感染治疗变得更加普遍后，脂肪性肝病很可能成为最常见的肝病。虽然脂肪肝与酒精、肥胖和代谢综合征有关，但其发病机制尚不清楚。脂肪肝、酒精性和非酒精性肝病(ALD)的发生和发展似乎都受到微生物区系组成的影响。肠道微生物区系已被证明影响肝病的肝硬变前期和肝硬变阶段，这可能导致对其诊断、治疗和研究的新策略。我们回顾了非酒精性脂肪性肝病(NAFLD)和ALD在肝硬变和肝硬变前阶段的区别和相似之处。在酒精相关疾病的这些阶段，继续饮酒的患者与停止饮酒的患者相比，在肠道微生物区系的组成和功能以及肠道完整性方面存在差异。糖尿病患者和非糖尿病患者之间的NAFLD和肠道微生物区系也不同。我们还讨论了微生物治疗NAFLD和ALD患者的潜力。
The prevalence of fatty liver diseases is increasing rapidly worldwide; after treatment of hepatitis C virus infection becomes more widespread, fatty liver diseases are likely to become most prevalent liver disorders. Although fatty liver diseases are associated with alcohol, obesity, and the metabolic syndrome, their mechanisms of pathogenesis are not clear. Development and progression of fatty liver, alcoholic, and non-alcoholic liver disease (ALD) all appear to be influenced by the composition of the microbiota. The intestinal microbiota have been shown to affect pre-cirrhotic and cirrhotic stages of liver diseases, which could lead to new strategies for their diagnosis, treatment, and study. We review differences and similarities in the cirrhotic and pre-cirrhotic stages of non-alcoholic fatty liver disease (NAFLD) and ALD. Differences have been observed in these stages of alcohol-associated disease in patients who continue to drink compared with those who stop, with respect to the composition and function of the intestinal microbiota and intestinal integrity. NAFLD and the intestinal microbiota also differ between patients with and without diabetes. We also discuss the potential of microbial therapy for patients with NAFLD and ALD.
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影响因子：
29.4
作者：
Chen P;Torralba M;Tan J;Embree M;Zengler K;Stärkel P;van Pijkeren JP;DePew J;Loomba R;Ho SB;Bajaj JS;Mutlu EA;Keshavarzian A;Tsukamoto H;Nelson KE;Fouts DE;Schnabl B
通讯作者：
Schnabl B
影响因子：
25.7
作者：
Fouts, Derrick E.;Torralba, Manolito;Nelson, Karen E.;Brenner, David A.;Schnabl, Bernd
通讯作者：
Schnabl, Bernd
影响因子：
2.9
作者：
Flint, Harry J.
通讯作者：
Flint, Harry J.
影响因子：
2.3
作者：
Bellentani, Stefano;Scaglioni, Federica;Bedogni, Giorgio
通讯作者：
Bedogni, Giorgio
DOI：
10.1111/acer.12900
发表时间：
2015-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Chen P;Miyamoto Y;Mazagova M;Lee KC;Eckmann L;Schnabl B
通讯作者：
Schnabl B