Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.
Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.
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DOI：
10.1016/j.freeradbiomed.2010.09.014
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发表时间：
2010-12-15
影响因子：
7.4
通讯作者：
Orr, William C.
中科院分区：
文献类型：
--
作者：
Radyuk, Svetlana N.;Rebrin, Igor;Klichko, Vladimir I.;Sohal, Barbara H.;Michalak, Katarzyna;Benes, Judith;Sohal, Rajindar S.;Orr, William C.
关键词：
Drosophila mitochondria contain two peroxidases, peroxiredoxin 3 (dPrx3) and peroxiredoxin 5 (dPrx5), which together constitute the sole known intra-mitochondrial mechanism for the catalytic removal of hydrogen-and organic-peroxides. dPrx3 exists exclusively within mitochondria, whereas dPrx5 is also present in some other intracellular compartments. Levels of these two peroxiredoxins were genetically manipulated, singly and together, in D. melanogaster, for the purpose of understanding their respective functions. Under-expression of dPrx3 by 90–95% had no discernable effect on life span under normal or oxidative stress conditions; the dPrx5 null flies were previously reported to exhibit a 10% shortening of mean life span and an increase in sensitivity to oxidative stress. Flies under-expressing both dPrx3 and dPrx5 showed an 80% decrease in life span, severe disruption in thiol homeostasis and a massive induction of apoptosis in the muscle and digestive system tissues. The early mortality in flies, under-expressing both peroxiredoxins, was partially offset by over-expression of thioredoxin reductase but not mitochondrion-targeted catalase. These results suggest that mitochondrial peroxiredoxins confer specific protection for thioredoxin/glutathione systems, play a critical role in the maintenance of global thiol homeostasis, prevent the age-associated apoptosis and premature death.
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影响因子：
4.5
作者：
Bao, Sujin;Cagan, Ross
通讯作者：
Cagan, Ross
DOI：
10.1046/j.1432-1327.1999.00162.x
发表时间：
1999-03-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Kropotov, A;Sedova, V;Tomilin, N
通讯作者：
Tomilin, N
影响因子：
3.5
作者：
Li, Lianqin;Shoji, Wataru;Kanno, Naoko
通讯作者：
Kanno, Naoko
影响因子：
4.1
作者：
TSUJI, K;COPELAND, NG;OBINATA, M
通讯作者：
OBINATA, M
影响因子：
3.7
作者：
Kropotov, Andrey;Gogvadze, Vladimir;Zhivotovsky, Boris
通讯作者：
Zhivotovsky, Boris