Therapeutic application of extracellular vesicles in kidney disease: promises and challenges.

Therapeutic application of extracellular vesicles in kidney disease: promises and challenges.
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细胞外囊泡在肾脏疾病中的治疗应用:前景与挑战

DOI:
10.1111/jcmm.13407
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发表时间:
2018-03
影响因子:
5.3
通讯作者:
Liu BC
Liu BC
中科院分区:
医学2区
文献类型:
--
作者:
Lv LL;Wu WJ;Feng Y;Li ZL;Tang TT;Liu BC

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细胞外囊泡(EV)是从不同细胞释放的纳米尺寸的膜结合囊泡。最近的研究表明,EVs可能通过介导肾单位间通讯参与肾组织损伤和再生。因此,EV作为治疗载体的潜在用途引起了相当大的兴趣。在这篇综述中,我们将讨论 EV 的基本特征及其在肾单位细胞通信中的作用。然后,讨论了EVs作为基于其天然含量的治疗载体或作为药物载体在急性和慢性肾损伤中的应用。最后,描述了 EV 在肾脏疾病治疗中的前景和挑战。
Extracellular vesicles (EVs) are nanosized, membrane‐bound vesicles released from different cells. Recent studies have revealed that EVs may participate in renal tissue damage and regeneration through mediating inter‐nephron communication. Thus, the potential use of EVs as therapeutic vector has gained considerable interest. In this review, we will discuss the basic characteristics of EVs and its role in nephron cellular communication. Then, the application of EVs as therapeutic vector based on its natural content or as carriers of drug, in acute and chronic kidney injury, was discussed. Finally, perspectives and challenges of EVs in therapy of kidney disease were described.
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