Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
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DOI：
10.1126/science.1258857
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发表时间：
2015-01-02
期刊：
影响因子：
--
通讯作者：
Wang MC
中科院分区：
文献类型：
--
作者：
Folick A;Oakley HD;Yu Y;Armstrong EH;Kumari M;Sanor L;Moore DD;Ortlund EA;Zechner R;Wang MC
Lysosomes are crucial cellular organelles for human health that function in digestion and recycling of extracellular and intracellular macromolecules. We describe a signaling role for lysosomes that affects aging. In the worm, Caenorhabditis elegans, the lysosomal acid lipase LIPL-4 triggered nuclear translocalization of a lysosomal lipid chaperone LBP-8, consequently promoting longevity by activating the nuclear hormone receptors NHR-49 and NHR-80. We used high-throughput metabolomic analysis to identify several lipids whose abundance was increased in worms constitutively over-expressing LIPL-4. Among them, oleoylethanolamide directly bound to LBP-8 and NHR-80 proteins, activated transcription of target genes of NHR-49 and NHR-80, and promoted longevity in C. elegans. These findings reveal a lysosome-to-nucleus signaling pathway that promotes longevity and suggest a function of lysosomes as signaling organelles in metazoans.
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DOI：
10.1038/nrm3565
发表时间：
2013-05
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
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影响因子：
9.8
作者：
Van Gilst MR;Hadjivassiliou H;Jolly A;Yamamoto KR
通讯作者：
Yamamoto KR
影响因子：
64.8
作者：
Fu, J;Gaetani, S;Piomelli, D
通讯作者：
Piomelli, D
DOI：
10.1073/pnas.95.22.13091
发表时间：
1998-10-27
影响因子：
11.1
作者：
Lakowski, B;Hekimi, S
通讯作者：
Hekimi, S
影响因子：
64.8
作者：
Ogg, S;Paradis, S;Ruvkun, G
通讯作者：
Ruvkun, G