Signals from the lysosome: a control centre for cellular clearance and energy metabolism.
Signals from the lysosome: a control centre for cellular clearance and energy metabolism.
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DOI：
10.1038/nrm3565
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发表时间：
2013-05
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--
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很长一段时间以来，溶酶体仅仅被认为是细胞的“焚化炉”，参与细胞废物的降解和再循环。然而，现在有令人信服的证据表明，溶酶体具有更广泛的功能，它们参与诸如分泌、质膜修复、信号传导和能量代谢等基本过程。此外，溶酶体在自噬途径中的重要作用使这些细胞器处于几个细胞过程的十字路口，对健康和疾病具有重要意义。调控溶酶体生物发生和自噬的主基因转录因子EB （TFEB）的鉴定，揭示了溶酶体如何适应环境因素，如饥饿，并提出了调节人类疾病溶酶体功能的新治疗策略。
For a long time lysosomes were considered merely to be cellular “incinerators” involved in the degradation and recycling of cellular waste. However, there is now compelling evidence indicating that lysosomes have a much broader function and that they are involved in fundamental processes such as secretion, plasma membrane repair, signaling and energy metabolism. Furthermore, the essential role of lysosomes in the autophagic pathway puts these organelles at the crossroads of several cellular processes, with significant implications for health and disease. The identification of a master gene, transcription factor EB (TFEB), that regulates lysosomal biogenesis and autophagy, has revealed how the lysosome adapts to environmental cues, such as starvation, and suggests novel therapeutic strategies for modulating lysosomal function in human disease.
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影响因子：
9.8
作者：
Chartier-Harlin, Marie-Christine;Dachsel, Justus C.;Farrer, Matthew J.
通讯作者：
Farrer, Matthew J.
影响因子：
56.9
作者：
CHIANG, HL;TERLECKY, SR;DICE, JF
通讯作者：
DICE, JF
影响因子：
4.8
作者：
Andrejewski, N;Punnonen, EL;Saftig, P
通讯作者：
Saftig, P
影响因子：
64.5
作者：
Cang C;Zhou Y;Navarro B;Seo YJ;Aranda K;Shi L;Battaglia-Hsu S;Nissim I;Clapham DE;Ren D
通讯作者：
Ren D
影响因子：
20.3
作者：
Cea, Michele;Cagnetta, Antonia;Anderson, Kenneth C.
通讯作者：
Anderson, Kenneth C.