The background and legacy of Lewontin's apportionment of human genetic diversity.
The background and legacy of Lewontin's apportionment of human genetic diversity.
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DOI：
10.1098/rstb.2020.0406
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发表时间：
2022-06-06
影响因子：
6.3
通讯作者：
Novembre, John
中科院分区：
文献类型：
--
作者：
Novembre, John
Lewontin 1972 年的文章“人类多样性的分配”描述了人类遗传多样性的一个关键特征，该特征将对有关遗传学和种族的对话产生深远的影响：经典人类种族群体之间的典型遗传位点差异比人们通过检查历史上用于定义这些种族的特征（例如皮肤色素沉着）所推断的要小得多。 Lewontin 由此得出结论：“人类种族分类……现在看来几乎没有遗传或分类学意义”（第 397 页）。在该论文发表 50 年后，我们的目标是了解该论文的起源和遗产。借助已发表论文的见解以及对 Lewontin 的几位同时代人的采访，我回顾了 1972 年的论文，询问了导致该论文发表的知识背景、其影响的发展、对该作品的批评以及该作品在当今的应用和局限性。希望通过更清楚地了解论文的起源和推理，我们可以消除对结果的各种困惑，并加深对结果提供的持久价值和见解的理解。本文是主题“庆祝 Lewontin 分配人类多样性 50 周年”的一部分。
Lewontin's 1972 article ‘The apportionment of human diversity’ described a key feature of human genetic diversity that would have profound impacts on conversations regarding genetics and race: the typical genetic locus varies much less between classical human race groupings than one might infer from inspecting the features historically used to define those races, like skin pigmentation. From this, Lewontin concluded: ‘Human racial classification … is now seen to be of virtually no genetic or taxonomic significance’ (p. 397). Here, 50 years after the paper's publication, the goal is to understand the origins and legacy of the paper. Aided by insights from published papers and interviews with several of Lewontin's contemporaries, I review the 1972 paper, asking about the intellectual background that led to the publication of the paper, the development of its impact, the critiques of the work and the work's application and limitations today. The hope is that by gaining a clearer understanding of the origin and reasoning of the paper, we might dispel various confusions about the result and sharpen an understanding of the enduring value and insight the result provides. This article is part of the theme issue ‘Celebrating 50 years since Lewontin's apportionment of human diversity’.
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影响因子：
64.8
作者：
BOWCOCK, AM;RUIZLINARES, A;CAVALLISFORZA, LL
通讯作者：
CAVALLISFORZA, LL
影响因子：
1.7
作者：
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DOI：
10.1016/j.shpsc.2014.12.005
发表时间：
2015-08-01
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通讯作者：
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DOI：
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发表时间：
2022-06-06
影响因子：
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通讯作者：
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