Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study.
Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study.
复制标题
慢性阻塞性肺疾病急性加重期患者外周血单个核细胞动态基因表达的初步研究。
DOI：
10.1186/s13054-014-0508-y
复制
发表时间：
2014-11-19
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Wu X;Sun X;Chen C;Bai C;Wang X
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a serious event that is responsible for the progress of the disease, increases in medical costs and high mortality. The aim of the present study was to identify AECOPD-specific biomarkers by evaluating the dynamic gene expression profiling of peripheral blood mononuclear cells (PBMCs) from patients with AECOPD on days 1, 3 and 10 after hospital admission and to compare the derived data with data from healthy controls or patients with stable COPD. We found that 14 genes were co–differentially upregulated and 2 downregulated greater than 10-fold in patients with COPD or AECOPD compared with the healthy individuals. Eight co–differentially upregulated genes and six downregulated genes were identified as a panel of AECOPD-specific genes. Downregulation of TCF7 in PBMCs was found to be associated with the severity of COPD. Dynamic changes of Aminolevulinate-delta-synthase 2 and carbonic anhydrase I had similar patterns of Digital Evaluation Score System scores and may serve as potential genes of interest during the course of AECOPD. Thus, our findings indicate a panel of altered gene expression patterns in PBMCs that can be used as AECOPD-specific dynamic biomarkers to monitor the course of AECOPD. The online version of this article (doi:10.1186/s13054-014-0508-y) contains supplementary material, which is available to authorized users.
登录
查看更多内容
通过在AECOPD患者中将炎症介体与临床信息学相结合：一项初步研究，选择了疾病特异性的生物标志物。
影响因子：
5.3
作者：
Chen H;Song Z;Qian M;Bai C;Wang X
通讯作者：
Wang X
影响因子：
24.3
作者：
Mannino, D. M.;Thorn, D.;Holguin, F.
通讯作者：
Holguin, F.
影响因子：
3.2
作者：
Llinas, Laia;Peinado, Victor I.;Bastos, Ricardo
通讯作者：
Bastos, Ricardo
影响因子：
10
作者：
Pinto-Plata, Victor;Toso, John;Celli, Bartolome
通讯作者：
Celli, Bartolome
DOI：
10.1186/1476-9255-9-1
发表时间：
2012-01-12
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Ngkelo A;Meja K;Yeadon M;Adcock I;Kirkham PA
通讯作者：
Kirkham PA