Nanoparticle-mediated thermal therapy: evolving strategies for prostate cancer therapy.
Nanoparticle-mediated thermal therapy: evolving strategies for prostate cancer therapy.
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DOI：
10.3109/02656736.2010.485593
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Cho SH
中科院分区：
文献类型：
--
作者：
Krishnan S;Diagaradjane P;Cho SH
纳米技术的最新进展导致了大量不同尺寸、形状、核心物理化学性质和表面修饰的纳米颗粒的制造，这些纳米颗粒正在被研究用于潜在的医疗应用，特别是癌症的治疗。本文综述了定制的金纳米粒子、磁性纳米粒子和碳纳米管的治疗应用，这些纳米粒子在直接注射到肿瘤内或全身给药后优先聚集在肿瘤中后，在电磁(光和磁场)刺激下高效产生热量。这篇综述还将集中在利用纳米颗粒介导的热疗提高前列腺癌治疗指数的不断发展的策略。纳米粒子介导的热疗是治疗癌症的一种新的微创工具。这种形式的热疗带来的独特挑战包括：系统给药时，纳米颗粒在网状内皮系统中的非靶向生物分布，无法可视化或量化这些颗粒在肿瘤内的全球浓度和空间分布，缺乏标准化的热模拟和剂量学算法，以及对它们的生物兼容性的担忧。然而，新颖的粒子组成、几何形状、激活策略、靶向技术、有效载荷传递策略和辐射剂量增强概念是这种形式的热疗的独特属性，值得进一步探索。利用这些机会并克服这些挑战，提供了将这种纳米颗粒介导的热疗范例从长凳上无缝而合乎逻辑地转换到床边的可能性。
Recent advances in nanotechnology have resulted in the manufacture of a plethora of nanoparticles with different sizes, shapes, core physicochemical properties and surface modifications that are being investigated for potential medical applications, particularly for the treatment of cancer. This review focuses on the therapeutic use of customized gold nanoparticles, magnetic nanoparticles and carbon nanotubes that efficiently generate heat upon electromagnetic (light and magnetic fields) stimulation after direct injection into tumors or preferential accumulation in tumors following systemic administration. This review will also focus on the evolving strategies to improve the therapeutic index of prostate cancer treatment using nanoparticle-mediated hyperthermia. Nanoparticle-mediated thermal therapy is a new and minimally invasive tool in the armamentarium for the treatment of cancers. Unique challenges posed by this form of hyperthermia include the non-target biodistribution of nanoparticles in the reticuloendothelial system when administered systemically, the inability to visualize or quantify the global concentration and spatial distribution of these particles within tumors, the lack of standardized thermal modeling and dosimetry algorithms, and the concerns regarding their biocompatibility. Nevertheless, novel particle compositions, geometries, activation strategies, targeting techniques, payload delivery strategies, and radiation dose enhancement concepts are unique attributes of this form of hyperthermia that warrant further exploration. Capitalizing on these opportunities and overcoming these challenges offers the possibility of seamless and logical translation of this nanoparticle-mediated hyperthermia paradigm from the bench to the bedside.
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影响因子：
3.5
作者：
Cheong, Seong-Kyun;Jones, Bernard L.;Cho, Sang Hyun
通讯作者：
Cho, Sang Hyun
影响因子：
11.5
作者：
Diagaradjane, Parmeswaran;Orenstein-Cardona, Jacobo M.;Krishnan, Sunil
通讯作者：
Krishnan, Sunil
影响因子：
3.5
作者：
Cho, SH
通讯作者：
Cho, SH
影响因子：
3.3
作者：
Arnida;Malugin, Alexander;Ghandehari, Hamidreza
通讯作者：
Ghandehari, Hamidreza
DOI：
10.1016/s0360-3016(97)00109-0
发表时间：
1997-03-15
影响因子：
7
作者：
Anscher, MS;Samulski, TV;Dewhirst, MW
通讯作者：
Dewhirst, MW