Sexual Dimorphic Interplays Between Gut Microbiota and Antihypertensive Drugs.
Sexual Dimorphic Interplays Between Gut Microbiota and Antihypertensive Drugs.
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DOI：
10.1007/s11906-023-01244-6
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发表时间：
2023-08
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是回顾目前关于肠道微生物群在血压调节及其与降压药物相互作用方面的文献，并讨论肠道微生物群的性别差异如何影响高血压的性别二型性和治疗。肠道菌群在血压调节和高血压病因学中的重要性日益被认识。靶向微生物群被认为是一种新的治疗方法。最近，一些研究表明，肠道菌群高度参与抗高血压药物疗效的调节，提示肠道菌群在难治性高血压中发挥作用的新机制。此外，对肠道微生物群的性别差异、高血压的病因学以及抗高血压药物处方中的性别偏见的研究揭示了基于性别二态性的精准医学的前景。然而，关于肠道菌群的性别差异如何影响某些类别抗高血压药物的性别特异性反应，从未提出过科学问题。鉴于个体之间的动态性和复杂性，精准医疗被认为具有巨大的潜力。我们回顾了目前关于肠道菌群、高血压和抗高血压药物之间相互作用的知识，强调性别是一个关键的决定因素。我们建议肠道菌群的性别差异是一个研究重点，以促进我们对高血压管理的理解。
The purpose of this study is to review the current literature regarding gut microbiota in blood pressure regulation and its interactions with antihypertensive drugs and to discuss how sex differences in gut microbiota contribute to sexual dimorphism of hypertension and treatment. The significance of gut microbiota in blood pressure regulation and hypertension etiology is growingly recognized. Targeting the dysbiotic microbiota is proposed to be a new therapeutic method. Recently, a few studies demonstrated that the gut microbiota is highly involved in the modulation of the efficacy of antihypertensive drugs, suggesting a novel mechanism by which gut microbiota plays a role in treatment-resistant hypertension. Furthermore, studies on sex differences in gut microbiota, etiology of hypertension, and sex bias in prescription of antihypertensive medications have revealed promising avenues in sexual dimorphism-based precision medicine. However, no scientific questions are ever raised on how sex differences in gut microbiota contribute to the sex specific responses of certain classes of antihypertensive drugs. Given the dynamics and complexity among individuals, precision medicine is proposed of great potential. We review current knowledge on the interactions between gut microbiota, hypertension, and antihypertensive drugs with an emphasis on sex as a crucial determinant. We propose that sex differences in gut microbiota be a research focus to advance our understanding of hypertension management.
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DOI：
10.1161/hyp.0000000000000084
发表时间：
2018-11
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Carey RM;Calhoun DA;Bakris GL;Brook RD;Daugherty SL;Dennison-Himmelfarb CR;Egan BM;Flack JM;Gidding SS;Judd E;Lackland DT;Laffer CL;Newton-Cheh C;Smith SM;Taler SJ;Textor SC;Turan TN;White WB;American Heart Association Professional/Public Education and Publications Committee of the Council on Hypertension; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Genomic and Precision Medicine; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council
通讯作者：
American Heart Association Professional/Public Education and Publications Committee of the Council on Hypertension; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Genomic and Precision Medicine; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council
影响因子：
3.2
作者：
Gu, Qiuping;Burt, Vicki L.;Dillon, Charles F.
通讯作者：
Dillon, Charles F.
DOI：
10.1152/ajpheart.00060.2021
发表时间：
2022-02-01
影响因子：
4.8
作者：
Ishimwe, Jeanne A.;Baker, Melanie B.;Sasser, Jennifer M.
通讯作者：
Sasser, Jennifer M.
影响因子：
8.3
作者：
Carey, Robert M.;Sakhuja, Swati;Muntner, Paul
通讯作者：
Muntner, Paul
影响因子：
39.3
作者：
Hou, Kaijian;Wu, Zhuo-Xun;Chen, Xuan-Yu;Wang, Jing-Quan;Zhang, Dongya;Xiao, Chuanxing;Zhu, Dan;Koya, Jagadish B.;Wei, Liuya;Li, Jilin;Chen, Zhe-Sheng
通讯作者：
Chen, Zhe-Sheng